Publications

Human health risk assessment of three smoke flavoring primary products

Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 202(Aug):115490; doi: 10.1016/j.fct.2025.115490. PMID: 40320068.

An investigation of the genotoxic potential of a well-characterized yerba mate extract

Doepker C, Rabert C, Heard P, Dubnicka T, Choksi N, Eapen A. 2024. An investigation of the genotoxic potential of a well-characterized yerba mate extract. Toxicol Rep 12(June):477–484; doi: 10.1016/j.toxrep.2024.04.007. PMID: 38708314.

Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures

Thompson CM, Brorby G, Keig-Shevlin Z, Smith R, Franzen A, Ulrich K, Blanchette AD, Doepker C. 2023. Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures. Environ Mol Mutagen 64(8–9):420–431; doi: 10.1002/em.22576. PMID: 37916278.

Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use

Henderson RG, Vincent M, Rivera BN, Bonn-Miller MO, Doepker C. 2023. Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use. Regul Toxicol Pharmacol 144(Oct):105482; doi: 10.1016/j.yrtph.2023.105482. PMID: 37634699.

Risk assessment of three smoke flavoring primary products currently under re-evaluation by EFSA

Franzen AC, Thompson CM, Brorby GP, Wikoff DS, Ilkbahar Z, Doepker C. Risk assessment of three smoke flavoring primary products currently under re-evaluation by EFSA. Poster presented at Society of Toxicology 62^nd Annual Meeting, Nashville, TN, March 2023.

Benefit-risk of coffee consumption and all-cause mortality: A systematic review and disability adjusted life year analysis

Doepker C, Movva N, Cohen SS, Wikoff DS. 2022. Benefit-risk of coffee consumption and all-cause mortality: A systematic review and disability adjusted life year analysis. Food Chem Toxicol 170(Dec):113472; doi: 10.1016/j.fct.2022.113472. PMID: 36243217.

Disparities in colorectal cancer time-to-treatment and survival time associated with racial and economic residential segregation surrounding the diagnostic hospital, Georgia 2010–2015

Leslie TF, Frankenfeld CL, Menon N. 2022. Disparities in colorectal cancer time-to-treatment and survival time associated with racial and economic residential segregation surrounding the diagnostic hospital, Georgia 2010–2015. Cancer Epidemiol 81:102267, https://doi.org/10.1016/j.canep.2022.102267.

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Assessing the food safety risk of ochratoxin A in coffee: A toxicology-based approach to food safety planning

Heintz MM, Doepker CL, Wikoff DS, Hawks SE. 2021. Assessing the food safety risk of ochratoxin A in coffee: A toxicology-based approach to food safety planning. J Food Sci 86(11):4799-4810; doi: 10.1111/1750-3841.15938.

Review of potential risks associated with supplementary dietary exposure to nitrate-containing compounds in swine — A paradox in light of emerging benefits

Doepker CD, Heintz MM, van de Ligt JLG, Wikoff DS. 2021. Review of potential risks associated with supplementary dietary exposure to nitrate-containing compounds in swine — A paradox in light of emerging benefits. Trans Anim Sci 5(4):txab203; doi: 10.1093/tas/txab203. PMID: 34909600.

Impact of calcium nitrate supplementation on the oxygen-carrying capacity of lactating sows and their offspring

van de Ligt JLG, Saddoris-Clemens KL, Norton SA, Davis MD, Doepker CL. 2021. Impact of calcium nitrate supplementation on the oxygen-carrying capacity of lactating sows and their offspring. Trans Anim Sci 5(4):txab217; doi: 10.1093/tas/txab217.

Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map

Fitch SE, Payne LE, van de Ligt JLG, Doepker C, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Pub Health 21(1):956; doi: 10.1186/s12889-021-10934-2. PMID: 34016063.

Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence

Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS. 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150(April):112045; doi: 10.1016/j.fct.2021.112045. PMID: 33587976.

Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence

Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141(July):111375; doi: 10.1016/j.fct.2020.111375.

Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence

Chappell GA, Borghoff SJ, Pham L, Doepker CL, Wikoff DS. 2020. Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110898; doi: 10.1016/j.fct.2019.110898.

Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence

Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110866; doi: 10.1016/j.fct.2019.110866.

Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS)

Fitch S, van de Ligt J, Payne L, Doepker C, Kleinman R, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2019. Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS). Open Science Framework.

Safety evaluation of L-theanine administered via hard chew to dogs

Henderson RG, Doepker C, Lopez JG. Safety evaluation of L-theanine administered via hard chew to dogs. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates

Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120:709-723; doi: 10.1016/j.fct.2018.08.031.

Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children

Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O’Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D. 2018. Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients 10(10):1536; doi: 10.3390/nu10101536.

A proposed ADI for nitrate

Doepker D, Tyndall K, Lane R, Wikoff D, Thompson C, Harvey S, Schmitt D. 2017. A proposed ADI for nitrate. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.