Publications
Toxicology (397 POSTS)
2025 (3 POSTS)
Reproductive and developmental toxicity screen (OECD TG 421) and extended one generation reproductive toxicity study (OECD TG 443) of decahydronaphthalene in Sprague Dawley rats
Rogers JM, Heintz MM, Haws LC. 2025. Reproductive and developmental toxicity screen (OECD TG 421) and extended one generation reproductive toxicity study (OECD TG 443) of decahydronaphthalene in Sprague Dawley rats. Regul Toxicol Pharmacol 160(Aug):105829; doi: 10.1016/j.yrtph.2025.105829. PMID: 40222475.
View AbstractIdentifying structural overlap between EDSP universe of chemicals and ToxCast/Tox21 using chemical clustering and uniform manifold approximation and projection
Cook B, Nelms M, Harris D, Bever RJ, Lynn SG, Williams D, Borghoff S, Edwards SW, Markey K. Identifying structural overlap between EDSP universe of chemicals and ToxCast/Tox21 using chemical clustering and uniform manifold approximation and projection. Abstract 4034, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractDisruption of energy homeostasis by chemical mixtures containing persistent pollutants in HepG2 and C2C12 cells
Jacobellis M, Garcia M, Bain L, Pearce J, Hunt K, Baldwin W. Disruption of energy homeostasis by chemical mixtures containing persistent pollutants in HepG2 and C2C12 cells. Abstract 4564, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View Abstract2024 (16 POSTS)
Rolling along: State of the science for tire related chemicals 6PPD and 6PPD-quinone
Lane R, Gill S, Miller EL, Kennedy S, Shankar P, Williams T, et al. Rolling along: State of the science for tire related chemicals 6PPD and 6PPD-quinone. Abstract 4.22.P-Mo-115, Society of Environmental Toxicology and Chemistry, 45th Annual Meeting, Fort Worth, TX, October 2024.
View AbstractQuality and reliability evaluation of 6PPD-quinone surface water occurrence data and considerations for use in risk assessment
Bare J, Kennedy SB, Feifarek D, Panko J. Quality and reliability evaluation of 6PPD-quinone surface water occurrence data and considerations for use in risk assessment. Abstract 4.22.P-Mo-119, Society of Environmental Toxicology and Chemistry, 45th Annual Meeting, Fort Worth, TX, October 2024.
An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis
Jackson JW, Frederick C Streich Jr, Pal A, Coricor G, Boston C, …, Wood M, et al. 2024. An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci Signal 17(844):eadn6052; doi: 10.1126/scisignal.adn6052. PMID: 38980922.
View AbstractAssessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay
Thompson CM, Dewhurst N, Moundous D, Borghoff SJ, Haws LC, Vasquez MZ. 2024. Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay. Environ Mol Mutagen 65(3–4):129–136; doi: 10.1002/em.22601. PMID: 38717101.
View AbstractSafety evaluation of 8 drug degradants present in over-the-counter cough and cold medications
Mihalchik AL, Choksi NY, Roe AL, Wisser M, Whitaker K, Seibert D, Deore M, Pavlick L, Wikoff DS. 2024. Safety evaluation of 8 drug degradants present in over-the-counter cough and cold medications. Regul Toxicol Pharmacol 149(May):105621; doi: 10.1016/j.yrtph.2024.105621. PMID: 38608922.
View AbstractChemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models
Nelms MD, Antonijevic T, Ring C, Harris DL, Bever RJ, Lynn SG, … Borghoff S, et al. 2024. Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models. Front Toxicol 6(April 17):1346767; https://doi.org/10.3389/ftox.2024.1346767. PMID: 38694816.
View AbstractComparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044. PMID: 38574381.
View AbstractComparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes
Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045. PMID: 38574385.
View AbstractStudy quality evaluation of literature reporting plastic microparticle exposure against reproductive and developmental toxicity endpoints
Fitch S, Ellis-Hutchings R, Rogers J, Marty S, Rushton E,… Wikoff D. Study quality evaluation of literature reporting plastic microparticle exposure against reproductive and developmental toxicity endpoints. Abstract 5159, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractOptimizing androgen receptor prioritization using high-throughput assay-based activity models
Edwards S, Antonijevic T, Nelms M, Ring C, Harris D,… Borghoff S, Markey K. Optimizing androgen receptor prioritization using high-throughput assay-based activity models. Abstract 4381, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractChemistry domain of applicability evaluation of estrogen receptor high-throughput assay-based activity models
Nelms M, Antonijevic T, Ring C, Harris D, Bever RJ,… Borghoff S, et al. Chemistry domain of applicability evaluation of estrogen receptor high-throughput assay-based activity models. Abstract 4380, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractEvidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA
Thompson CM, Heintz MM, Rogers SI, Fitch SE, Rivera BN, Klaren WD, Vincent MJ, Wikoff DS, Haws LC. Evidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA. Abstract 3654, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractDelayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes
Heintz M, Klaren W, East A, Haws L, Thompson C. Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractNonclinical safety evaluation of 1-monoacetin and 2-monoacetin as potential impurities in pharmaceutical excipients
Petrick J, Mihalchik A, Tiwary A, Kreidl L, Swartz C, Bhattarai N. Nonclinical safety evaluation of 1-monoacetin and 2-monoacetin as potential impurities in pharmaceutical excipients. Abstract 3107, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractOptimizing androgen receptor prioritization using high-throughput assay-based activity models
Bever RJ, Edwards SW, Antonijevic T, Nelms MD, Ring C, Harris D, Lynn SG, Williams D, Chappell G, Boyles R, Borghoff S, Markey KJ. 2024. Optimizing androgen receptor prioritization using high-throughput assay-based activity models. Front Toxicol 6(March 11):1347364; doi: 10.3389/ftox.2024.1347364. PMID: 38529103.
View AbstractUnexpected thermal stability of two enveloped megaviruses, Emiliania huxleyi virus and African swine fever virus, as measured by viability PCR
Balestreri, Schroeder DC, Sampedro F, Marqués G, Palowski A, Urriola PE, van de Ligt JLG, Yancy HF, Shurson GC. 2024. Unexpected thermal stability of two enveloped megaviruses, Emiliania huxleyi virus and African swine fever virus, as measured by viability PCR. Virol J 21(1);1; doi: 10.1186/s12985-023-02272-z. PMID: 8172919.
View Abstract2023 (11 POSTS)
Physiologically-based pharmacokinetic model to predict HFC-134a in exhaled breath following albuterol inhaler use.
Covington TR, Sterner TR. Physiologically-based pharmacokinetic model to predict HFC-134a in exhaled breath following albuterol inhaler use. Poster presented at the 2023 Toxicology and Risk Assessment Conference, Miamisburg, OH, August 25, 2023.