Publications
carcinogens (54 POSTS)
2025 (4 POSTS)
Evaluation of the chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) in mice
Thompson CM, Heintz MM, Cullen JM, Haws LC. Evaluation of the chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) in mice. Abstract 4700, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractSystematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data
Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton EK, Borghoff SJ. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractSystematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data
Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractSystematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data
Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.
View Abstract2023 (2 POSTS)
Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data”
Thompson CM, Proctor DM, Harris MA. 2023. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.” Environ Mol Mutagen 64(4):259–260; doi: 10.1002/em.22537. PMID: 36916184.
Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame
Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.
View Abstract2022 (1 POST)
In silico approaches in carcinogenicity hazard assessment: Current status and future needs
Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J…, Mihalchik-Burhans AL, et al. 2021. In silico approaches in carcinogenicity hazard assessment: Current status and future needs. Comp Toxicol 20(Nov):100191; doi: 10.1016/j.comtox.2021.100191.
View Abstract2021 (6 POSTS)
Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene
Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova NY, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383; doi: 10.1021/acs.chemrestox.1c00291. PMID: 34726909.
View AbstractA review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment
Thompson CM, Aardema MJ, Heintz MM, MacGregor JT, Young RR. 2021. A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment. Crit Rev Toxicol 51(10)820-849; doi: 10.1080/10408444.2021.2000934. PMID: 35060824.
View AbstractQuantitative nanoLC/NSI+-HRMS method for 1,3-butadiene induced bis-N7-guanine DNA-DNA cross-links in urine
Erber L, Goodman S, Jokipii Krueger CC, Rusyn I, Tretyakova N. 2021. Quantitative nanoLC/NSI+-HRMS method for 1,3-butadiene induced bis-N7-guanine DNA-DNA cross-links in urine. Toxics 9(10):247; doi: 10.3390/toxics9100247. PMID: 34678943.
View AbstractAssessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential
Jaeschke H, Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Atillasoy E… Wikoff D, et al. 2021. Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regul Toxicol Pharmacol 120(March):104859; doi: 10.1016/j.yrtph.2020.104859. PMID: 33388367.
View AbstractLack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS. 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150(April):112045; doi: 10.1016/j.fct.2021.112045. PMID: 33587976.
View AbstractButylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply?
Felter SP, Zhang X, Thompson C. 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121(April):104887; doi: 10.1016/j.yrtph.2021.104887.
View Abstract2020 (6 POSTS)
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D, Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118(Dec):104788; doi: 10.1016/j.yrtph.2020.104788.
View AbstractExposure to 1,4-dioxane above the metabolic saturation threshold induces a mitogenic key element in the mouse liver cancer mode of action
Lafranconi M, Budinsky R, Corey L, Haws L, Klapacz J, Chappell G, Golden R. Exposure to 1,4-dioxane above the metabolic saturation threshold induces a mitogenic key element in the mouse liver cancer mode of action. Abstract #1505. Society of Toxicology 59th Annual Meeting, Virtual, 2020.
View AbstractLack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence
Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141(July):111375; doi: 10.1016/j.fct.2020.111375.
View AbstractEvaluation of two in silico programs for predicting mutagenicity and carcinogenicity potential for 4-methylimidazole (4-MeI) and known metabolites
Howard AS, Choksi NY. 2020. Evaluation of two in silico programs for predicting mutagenicity and carcinogenicity potential for 4-methylimidazole (4-MeI) and known metabolites. Toxicol Mech Method 30:246–256; doi: 10.1080/15376516.2019.1709237.
View AbstractTg.rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals: Industry survey of current practice
Bogdanfy MS, Lesnick J, Mangipudy R, Sistare FD, Colman K, Garcia-Tapla D, Monticello T, Blanset D. 2020. Tg.rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals: Industry survey of current practices. Int J Toxicol 39(3):198-206; doi: 10.1177/1091581820919896.
View AbstractLack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence
Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110866; doi: 10.1016/j.fct.2019.110866.
View Abstract2019 (3 POSTS)
Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment
Clewell RA, Thompson CM, Clewell HJ. 2019. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chem Biol Interact 301(March):112–127; doi: 10.1016/j.cbi.2019.01.025.
View Abstract