Publications
genotoxicity (25 POSTS)
2025 (1 POST)
Human health risk assessment of three smoke flavoring primary products
Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 202(Aug):115490; doi: 10.1016/j.fct.2025.115490. PMID: 40320068.
View Abstract2023 (3 POSTS)
Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures
Thompson CM, Brorby G, Keig-Shevlin Z, Smith R, Franzen A, Ulrich K, Blanchette AD, Doepker C. 2023. Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures. Environ Mol Mutagen 64(8–9):420–431; doi: 10.1002/em.22576. PMID: 37916278.
View AbstractDerivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data
Thompson CM, Kirman C, Harris MA. 2023. Derivation of oral cancer slope factors for hexavalent chromium informed by pharmacokinetic models and in vivo genotoxicity data. Regul Toxicol Pharmacol 145(Dec):105521; doi: 10.1016/j.yrtph.2023.105521. PMID: 37863416.
View AbstractGenotoxicity evaluation of cannabidiol
Henderson RG, Welsh BT, Trexler KR, Bonn-Miller MO, Lefever TW. 2023. Genotoxicity evaluation of cannabidiol. Regul Toxicol Pharmacol 142(August):105425; doi: 10.1016/j.yrtph.2023.105425. PMID: 37271419.
View Abstract2022 (1 POST)
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review
Goodman S, Chappell G, Guyton KZ, Pogribny IP, Rusyn I. 2022. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review. Mutat Res Rev Mutat Res 789(Jan-Jun):108408; doi: 10.1016/j.mrrev.2021.108408. PMID: 35690411.
View Abstract2021 (2 POSTS)
A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment
Thompson CM, Aardema MJ, Heintz MM, MacGregor JT, Young RR. 2021. A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment. Crit Rev Toxicol 51(10)820-849; doi: 10.1080/10408444.2021.2000934. PMID: 35060824.
View AbstractOverall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence
Lea IA, Chappell GA, Wikoff DS. 2021. Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutat Res Genet Toxicol Environ Mutagen 868–869(Aug-Sept):503389; doi: 10.1016/j.mrgentox.2021.503389. PMID: 34454695.
View Abstract2019 (1 POST)
An integrated approach for animal-free genotoxicity testing: In vitro and in silico evaluation and mode-of-action classification
Swartz C, Howard AS, Choksi N, Rauer A, Allen DG, Recio L, Karmaus AL. An integrated approach for animal-free genotoxicity testing: In vitro and in silico evaluation and mode-of-action classification. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
View Abstract2018 (1 POST)
An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events
Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016.
View Abstract2016 (1 POST)
Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay
Thompson CM, Suh M, Proctor DM, Rager JE, Haws LC, Harris MA. Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.
View Abstract2013 (1 POST)
Steviol glycoside safety: Is the genotoxicity database sufficient?
Urban JD, Carakostas MC, Brusick DJ. 2013. Steviol glycoside safety: Is the genotoxicity database sufficient? Food Chem Toxicol 51(Jan):386-390; doi: 10.1016/j.fct.2012.10.016.
View Abstract2012 (5 POSTS)
Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats
Schmitt D, Tran N, Peach J, Bauter M, Marone P. 2012. Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. Food Chem Toxicol 50(10):3567–3576; doi: 10.1016/j.fct.2012.07.054. PMID: 22898615.
View AbstractAssessment of genotoxic potential of Cr(VI) in the intestine via in vivo intestinal micronucleus assay and in vitro high content analysis in differentiated and undifferentiated caco-2
Harris MA, Thompson CM, Wolf JC, Fedorov Y, Hixon JG, Proctor DM, Suh M, Haws LC. Assessment of genotoxic potential of Cr(VI) in the intestine via in vivo intestinal micronucleus assay and in vitro high content analysis in differentiated and undifferentiated caco-2. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
View AbstractAssessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis
Thompson CM, Fedorov Y, Brown DD, Suh M, Proctor DM, Kuriakose L, Haws L, Harris MA. 2012. Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis. PLoS ONE 7(8):e42720; doi: 10.1371/journal.pone.0042720.
View AbstractAssessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues
Thompson CM, Hixon JG, Proctor DM, Haws LC, Suh M, Urban JD, Harris MA. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues. Regul Toxicol Pharmacol 64(1):68-76; doi: 10.1016/j.yrtph.2012.05.019
View AbstractAssessment of genotoxic potential of Cr(VI) in the mouse duodenum via toxicogenomic profiling
Thompson CM, Hixon JG, Kopec AK, Harris MA, Proctor DM, Haws LC. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum via toxicogenomic profiling. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
View Abstract2011 (1 POST)
Dealing with positive in vitro mammalian cell genotoxicity assays
Robison TW. 2011. Dealing with positive in vitro mammalian cell genotoxicity assays. Inter Drug Discovery 6(5):40-43.
View Abstract2010 (5 POSTS)
Genotoxic impurity guidance – Current experiences, FDA perspective
Robison TW. Genotoxic impurity guidance – Current experiences, FDA perspective. USP Annual Meeting, New Orleans, LA, December 2010.
Dealing with positive in vitro mammalian cell genotoxicity assays
Robison TW. Dealing with positive in vitro mammalian cell genotoxicity assays. IQPC Genotoxicity and Carcinogenicity Testing 2010 Conference, London, UK, October 2010.
Dealing with genotoxic impurities from a regulatory perspective
Robison TW. Dealing with genotoxic impurities from a regulatory perspective. IQPC Genotoxicity and Carcinogenicity Testing 2010 Conference, London, UK, October 2010.