Publications

Adverse outcome pathways (AOPs) (8 POSTS)

2025 (2 POSTS)

AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting

Reynolds JI, Johnson BP. 2025. AOP 460: Antagonism of Smoothened receptor leads to orofacial clefting. ALTEX; doi: 10.14573/altex.2407121. Advance online publication August 11, 2025.

View Abstract

Bridging data gaps in sonic hedgehog signaling: A novel microphysiological model approach

Reynolds JI, Yelleti A, Johnson BP. Bridging data gaps in sonic hedgehog signaling: A novel microphysiological model approach. Abstract 3234, Society for Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

View Abstract

2024 (2 POSTS)

Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation

Reynolds JI, Choi J, Johnson BP. 2024. Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation. Curr Res Toxicol 7(Aug 8):100191; doi: 10.1016/j.crtox.2024.100191. PMID: 39205829.

View Abstract

AOP Network: Disruption of sonic hedgehog leading to orofacial clefts

Reynolds JI, Johnson B. AOP Network: Disruption of sonic hedgehog leading to orofacial clefts. Abstract 3625, Society of Toxicology 63rd Annual Meeting, Salt Lake City, 2024.

View Abstract

2023 (1 POST)

Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation

Johnson BP, Reynolds JI. Crowdsourcing AOP development: Leveraging the thesis literature review to identify knowledge gaps and facilitate research translation. Society for Birth Defects Research and Prevention 63rd Annual Meeting, Charleston, SC, 2023.

2021 (1 POST)

Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs)

Wikoff D, Edwards S, Angrish M, Baumgartner, Bever R, Borghoff S, Chappell G, Chew R, Fitch S, Hench G, Hamernik K, Henderson D, Kirk A, Lea I, Mandel M, Payne L, Shapiro S, Urban J, Williams D, Markey K. Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs). Presented at 10th annual meeting of American Society for Cellular and Computational Toxicology (virtual), October 2021.

View Abstract

2020 (1 POST)

An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N)

Franzen A, Borghoff SJ. An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N). Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.

View Abstract

2018 (1 POST)

An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016.

View Abstract