Publications
William D. Klaren (56 POSTS)
2016 (6 POSTS)
Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity
Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851–859; 10.1021/acs.chemrestox.6b00022. PMID: 26967026.
View Abstract2015 (7 POSTS)
PCB126-mediated disruption of hepatic metal homeostasis in mice and the role of metallothionein
Klaren WD, Robertson LW. PCB126-mediated disruption of hepatic metal homeostasis in mice and the role of metallothionein. Society of Toxicology 54th Annual Meeting, San Diego, CA, 2015.
View AbstractSpatial distribution of hepatic metals following PCB126 exposure
Klaren WD, Vine D, Vogt S, Robertson LW. Spatial distribution of hepatic metals following PCB126 exposure. Society of Toxicology, Central States Regional Chapter Annual Meeting, Kansas City, Ks, 2015.
PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Society of Toxicology, Central States Regional Chapter Annual Meeting, Kansas City, KS, 2015.
PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
Progression of micronutrient alteration and hepatotoxicity following acute exposure to PCB126
Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Ludewig G, Robertson LW. 2015. Progression of micronutrient alteration and hepatotoxicity following acute exposure to PCB126. Toxicol 338(Dec):1–7; doi: 10.1016/j.tox.2015.09.004. PMID: 26410179.
View AbstractProgression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure.
Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Robertson LW. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Best Poster Award, Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
View Abstract2014 (1 POST)
PCB126-mediated disruption of hepatic metal homeostasis in mice coincides with increased metallothionein expression and appears to be independent of the canonical AhR pathway
Klaren WD, Robertson LW. PCB126-mediated disruption of hepatic metal homeostasis in mice coincides with increased metallothionein expression and appears to be independent of the canonical AhR pathway. Best Poster Award, University of Iowa Research Week, 2014.
2013 (4 POSTS)
Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rodents
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rodents. Society of Toxicology 52nd Annual Meeting, San Antonio, Tx, 2013.
PCB126 induced increases in metallothionein expression may be species specific and AhR dependent
Klaren WD, Robertson LW. PCB126 induced increases in metallothionein expression may be species specific and AhR dependent. Society of Toxicology, Central States Regional Chapter Annual Meeting, Ames, IA, 2013.
Increases in metallothionein expression caused by PCB126 are linked to species sensitivity and are potentially mediated through the AhR
Klaren WD, Robertson LW. Increases in metallothionein expression caused by PCB126 are linked to species sensitivity and are potentially mediated through the AhR. Superfund Annual Meeting, Baton Rouge, LA, 2013.
Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?
Lai IK*, Klaren WD*, Li M, Wels B, Simmons DL, Olivier AK, Haschek WM, Wang K, Ludewig G, and Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver? Chem Res Toxicol 26(5):634–644 (*Co-First Authors); doi: 10.1021/tx400049s. PMID: 23527585.
View Abstract2012 (3 POSTS)
Regulation of MnSOD by the AhR agonist PCB126: The role of dietary manganese
Wang B, Wels BR, Klaren WD, Wang K, Robertson LW, Ludewig G. Regulation of MnSOD by the AhR agonist PCB126: The role of dietary manganese. Society of Toxicology 51st Annual Meeting, San Francisco, Ca, 2012. Also presented at Superfund Annual Meeting, Lexington, Ky, 2012.
View AbstractSearch for the basis of PCB-triggered disruption in hepatic copper in rodents
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB-triggered disruption in hepatic copper in rodents. Best Poster Award, University of Iowa Research Week, Iowa City, IA, 2012.
Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rats
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rats. Superfund Annual Meeting, Raleigh, NC and Society of Toxicology, Central States Regional Chapter Annual Meeting, Manhattan, KS, 2012.