Publications
PCBs (39 POSTS)
2020 (1 POST)
Cardiovascular effects of polychlorinated biphenyls and their major metabolites
Grimm FA, Klaren WD, Li X, Lehmler HJ, Karmakar M, Robertson LW, Chiu WA. Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Persp 128(7):77008; doi: 10.1289/EHP7030. PMID: 32701041.
View Abstract2018 (1 POST)
Cardiotoxicity screening of polychlorinated biphenyls and their major metabolites
Grimm FA, Klaren WD, Li X, House JS, Chiu W, Lehmler HJ, Robertson LW, Rusyn I. Cardiotoxicity screening of polychlorinated biphenyls and their major metabolites. Society of Toxicology 57th Annual Meeting, San Antonio, TX, 2018.
View Abstract2017 (2 POSTS)
Diminished phosphorylation of CREB Is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB Is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology 56th Annual Meeting, Baltimore, MD, and NIEHS Environmental Health Science FEST, Durham, NC, 2017.
View AbstractDoes PCB exposure cause non-Hodgkins lymphoma? A weight of evidence evaluation
Finley BL, Scott PK, Burns AM, Marsh GM. Does PCB exposure cause non-Hodgkins lymphoma? A weight of evidence evaluation. Abstract 3240, Society of Toxicology 56th Annual Meeting, Baltimore, MD, 2017.
2016 (3 POSTS)
Evaluation of the spatial distribution of hepatic metals following PCB126 exposure with x-ray fluorescence microscopy
Klaren WD, Vine D, Vogt S, Robertson LW. Evaluation of the spatial distribution of hepatic metals following PCB126 exposure with x-ray fluorescence microscopy. Society of Toxicology 55th Annual Meeting, New Orleans, LA, 2016.
View AbstractDiminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology, Central States Regional Meeting, Iowa City, IA, 2016. Also presented at NIEHS Obesity Grantee Meeting and 25 Years of Endocrine Disruption Workshop, NIH, Bethesda, MD, 2016.
Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat
Wang BW, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat. Toxicol Sci 150(1):15–26; doi: 10.1093/toxsci/kfv312. PMID: 26660635.
View Abstract2015 (5 POSTS)
PCB126-mediated disruption of hepatic metal homeostasis in mice and the role of metallothionein
Klaren WD, Robertson LW. PCB126-mediated disruption of hepatic metal homeostasis in mice and the role of metallothionein. Society of Toxicology 54th Annual Meeting, San Diego, CA, 2015.
View AbstractSpatial distribution of hepatic metals following PCB126 exposure
Klaren WD, Vine D, Vogt S, Robertson LW. Spatial distribution of hepatic metals following PCB126 exposure. Society of Toxicology, Central States Regional Chapter Annual Meeting, Kansas City, Ks, 2015.
Progression of micronutrient alteration and hepatotoxicity following acute exposure to PCB126
Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Ludewig G, Robertson LW. 2015. Progression of micronutrient alteration and hepatotoxicity following acute exposure to PCB126. Toxicol 338(Dec):1–7; doi: 10.1016/j.tox.2015.09.004. PMID: 26410179.
View AbstractProgression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure.
Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Robertson LW. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Best Poster Award, Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
View Abstract2014 (1 POST)
PCB126-mediated disruption of hepatic metal homeostasis in mice coincides with increased metallothionein expression and appears to be independent of the canonical AhR pathway
Klaren WD, Robertson LW. PCB126-mediated disruption of hepatic metal homeostasis in mice coincides with increased metallothionein expression and appears to be independent of the canonical AhR pathway. Best Poster Award, University of Iowa Research Week, 2014.
2013 (2 POSTS)
Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rodents
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rodents. Society of Toxicology 52nd Annual Meeting, San Antonio, Tx, 2013.
Increases in metallothionein expression caused by PCB126 are linked to species sensitivity and are potentially mediated through the AhR
Klaren WD, Robertson LW. Increases in metallothionein expression caused by PCB126 are linked to species sensitivity and are potentially mediated through the AhR. Superfund Annual Meeting, Baton Rouge, LA, 2013.
2012 (4 POSTS)
Regulation of MnSOD by the AhR agonist PCB126: The role of dietary manganese
Wang B, Wels BR, Klaren WD, Wang K, Robertson LW, Ludewig G. Regulation of MnSOD by the AhR agonist PCB126: The role of dietary manganese. Society of Toxicology 51st Annual Meeting, San Francisco, Ca, 2012. Also presented at Superfund Annual Meeting, Lexington, Ky, 2012.
View AbstractSearch for the basis of PCB-triggered disruption in hepatic copper in rodents
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB-triggered disruption in hepatic copper in rodents. Best Poster Award, University of Iowa Research Week, Iowa City, IA, 2012.
Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rats
Klaren WD, Lai IK, Robertson LW. Search for the basis of PCB126-triggered disruption of hepatic metal homeostasis in rats. Superfund Annual Meeting, Raleigh, NC and Society of Toxicology, Central States Regional Chapter Annual Meeting, Manhattan, KS, 2012.
PCB concentrations in shrimp from major import markets and the United States
Fillos D, Scott LLF, Anderle De Sylor M, Grespin M, Luksemburg WJ, Finley B. 2012. PCB concentrations in shrimp from major import markets and the United States. Environ Toxicol Chem 31(5):1063–1071; doi: 10.1002/etc.1803. PMID: 22407850.
View Abstract2011 (1 POST)
Endometriosis in a cohort of women living in the Kanawha River Valley in West Virginia: Blood levels of non-dioxin-like PCBs and relationship with BMI and age
Diliberto JJ, Sirinek L, Burkhalter B, Wikoff DS, Hixon G, Becker J, Patterson DG, Turner W, Tachovsky JA, Birnbaum LS, Haws LC. Endometriosis in a cohort of women living in the Kanawha River Valley in West Virginia: Blood levels of non-dioxin-like PCBs and relationship with BMI and age. Presented at Dioxin 2011, Brussels, Belgium, August 2011.