Publications
Wikoff, Daniele, Ph.D. (197 POSTS)
2025 (10 POSTS)
Systematic review of potential developmental and reproductive toxicity of microplastics
Fitch S, Rogers J, Marty S, Norman J, Schneider S, Rushton E, Wikoff D, Ellis-Hutchings R. 2025. Systematic review of potential developmental and reproductive toxicity of microplastics. Toxicol Sci kfaf108; doi: 10.1093/toxsci/kfaf108. Online ahead of print August 5, 2025. PMID: 40794567.
View AbstractHuman health risk assessment of three smoke flavoring primary products
Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 202(Aug):115490; doi: 10.1016/j.fct.2025.115490. PMID: 40320068.
View AbstractHow to organize a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024
Diemar MG, Giusti A, Michel-Caillet C, Leme DM, Wikoff D, Bloch D, Sass J, Beekmann K, et al. 2025. How to organize a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024. Arch Toxicol 99(7):3057-3063; doi: 10.1007/s00204-025-04064-6. PMID: 40372420.
View AbstractAn introduction to evidence integration
Wikoff D. An introduction to evidence integration. Workshop Session, Abstract 1333, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractBiological plausibility assessment of acetaminophen and occurrence of developmental neurological outcomes in humans
Wikoff D, Fitch S, Vincent M, Southall MD, Atillasoy E, Weinstein RD, Ejaz SD, Rhoden JD, Choksi N. Biological plausibility assessment of acetaminophen and occurrence of developmental neurological outcomes in humans. Abstract 4768, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025. (Honored as one of the Risk Assessment Specialty Section’s Top 10 Abstracts).
View AbstractAssessment of relative potency factors for six phthalates
Fitch S, Wikoff D, Foreman J, Buerger A, Haws L, Palmero C. Assessment of relative potency factors for six phthalates. Abstract 4235, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractApplication of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response
Wikoff DS, Vincent MJ, Heintz MM, Pastula ST, Reichert H, Klaren WD, Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152. PMID: 39792025.
View AbstractUse cases of strategic application of ML/AI in the risk assessment process
Wikoff D. Use cases of strategic application of ML/AI in the risk assessment process. Toxicology Forum 2025 Winter Meeting, Raleigh, NC, February 2025.
Pragmatic solutions for better using evidence-based methods to integrate observational data in food safety assessments
Wikoff D. Pragmatic solutions for better using evidence-based methods to integrate observational data in food safety assessments. Toxicology Forum 2025 Winter Meeting, Raleigh, NC, February 2025.
An integrated ecotoxicological study reliability framework for use in toxicity value development
Kennedy SB, Heintz MM, Klaren WD, Wikoff DS, Haws LC, Fitch SE. 2025. An integrated ecotoxicological study reliability framework for use in toxicity value development. Environ Tox Chem 44(4):1142-1153; doi: 10.1093/etojnl/vgaf030. PMID: 39873747.
View Abstract2024 (14 POSTS)
A review of low- and no-calorie sweetener safety and weight management efficacy
Mattes RD, Rivera BN, Rutigliani GR, Rogers S, Mendoza ID, Wang L, Beckemeier K, Wikoff D. 2024. A review of low- and no-calorie sweetener safety and weight management efficacy. Nutrition Today 59(6):261-288; doi: 10.1097/NT.0000000000000723.
View AbstractEditorial: Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology
Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM,… Wikoff D, Wright F, Whaley P. 2024. Editorial: Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol 98(8):2299-2308; doi: 10.1007/s00204-024-03802-6. PMID: 38877155.
View AbstractAssessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility
Vincent MJ, Fitch S, Bylsma L, Thompson C, Rogers S, Britt J, Wikoff D. 2024. Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility. Toxicol Sci 199(2):172–193; doi: 10.1093/toxsci/kfae039. PMID: 38547404.
View AbstractEvidence‐based methods in toxicology: Systematic review and systematic evidence mapping
Wikoff D, Fitch S. 2024. Evidence‐based methods in toxicology: Systematic review and systematic evidence mapping. Chapter 32 in: Paustenbach DJ (ed), Human and Ecological Risk Assessment: Theory and Practice, Third Edition, pp. 1133–1148. Wiley, ISBN: 978-1-119-74296-8.
Safety evaluation of 8 drug degradants present in over-the-counter cough and cold medications
Mihalchik AL, Choksi NY, Roe AL, Wisser M, Whitaker K, Seibert D, Deore M, Pavlick L, Wikoff DS. 2024. Safety evaluation of 8 drug degradants present in over-the-counter cough and cold medications. Regul Toxicol Pharmacol 149(May):105621; doi: 10.1016/j.yrtph.2024.105621. PMID: 38608922.
View AbstractStudy quality evaluation of literature reporting plastic microparticle exposure against reproductive and developmental toxicity endpoints
Fitch S, Ellis-Hutchings R, Rogers J, Marty S, Rushton E,… Wikoff D. Study quality evaluation of literature reporting plastic microparticle exposure against reproductive and developmental toxicity endpoints. Abstract 5159, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractIntegration of toxicological and epidemiological information to evaluate biological plausibility and causality of associations between inhaled formaldehyde (FA) and lymphohematopoietic (LHP) cancers
Vincent M, Fitch S, Bylsma L, Thompson C, Rogers S, Britt J, Wikoff D. Integration of toxicological and epidemiological information to evaluate biological plausibility and causality of associations between inhaled formaldehyde (FA) and lymphohematopoietic (LHP) cancers. Abstract 5157, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractDioxin-like compounds in soils: A pilot survey updating background soil TEQ
Urban JD, Covington TR, Fitch SE, Wikoff DS. Dioxin-like compounds in soils: A pilot survey updating background soil TEQ. Abstract 5147, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractDevelopment and application of systematic approach to inventory and interrogate thyroid hormone network information
Lynn SG, Lea IA, Urban J, Borghoff SJ, Wikoff D, Fitch S, Perry C, Choksi N, Britt J, Heintz M, Klaren W, et al. Development and application of systematic approach to inventory and interrogate thyroid hormone network information. Abstract 4357, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractEvidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA
Thompson CM, Heintz MM, Rogers SI, Fitch SE, Rivera BN, Klaren WD, Vincent MJ, Wikoff DS, Haws LC. Evidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA. Abstract 3654, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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