Abstracts and Presentations (1104 POSTS)

2016 (59 POSTS)

Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas

Suh M. Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas. Presented in the “Quantitative Cumulative Risk Assessment: Is it Feasible Today?” Session at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Non-mutagenic MOA for Cr(VI) involving intestinal cytotoxicity and regenerative hyperplasia

Thompson CM. Non-mutagenic MOA for Cr(VI) involving intestinal cytotoxicity and regenerative hyperplasia. Platform presentation in the “The Cancer Risk Assessment for Ingested Hexavalent Chromium: Challenges and Controversies” Session. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration

Borghoff SJ,  Wikoff D, Rager JE, Haws LC. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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The effects of a high fat (HF) diet on male diversity outbred (DO) mice

DeVito MJ, Borghoff SJ, Zorilla LM, Shockley K, Kissling G,  Travlos G. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Re-evaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from four studies of hexavalent chromium in drinking water

Cullen JM, Ward JM, Thompson CM. Re-evaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from four studies of hexavalent chromium in drinking water. Presented at Society of Toxicology 55th Annual Meeting, March 13-17, New Orleans, LA, March 2016.

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Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay

Thompson CM, Suh M, Proctor DM, Rager JE, Haws LC, Harris MA. Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers

Suh M, Crump K, Mittal L, Hirsch S, Valdes Salgado R, Bartlett C, Van Landingham C, Rohr A, Proctor DM. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Inhalation cancer risk assessment of cobalt metal

Brorby GP, Suh M, Thompson CM, Mittal L, Proctor DM. Inhalation cancer risk assessment of cobalt metal. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Principal component analysis of metals in soil and dust to distinguish background and anthropogenic sources in an urban area

Verwiel A, Proctor D, Tachovsky A. 2016. Principal component analysis of metals in soil and dust to distinguish background and anthropogenic sources in an urban area. Association for Environmental Health and Sciences Foundation Annual Meeting, San Diego, CA, March 2016.

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An in vitro test method for screening potential androgenic agonists and antagonists in mda-kb2 cells

Yang C, Casey W, Choksi N, Ceger P, Kleinstreuer N, Allen D, et al. An in vitro test method for screening potential androgenic agonists and antagonists in mda-kb2 cells. Poster presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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In vitro to in vivo extrapolation for estrogenic activity of environmental chemicals

Chang X, Kleinstreuer N, Ceger P, Choksi N, Hseih J-H, Wetmore BA et al. In vitro to in vivo extrapolation for estrogenic activity of environmental chemicals. Poster presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Multivariate models for prediction of human skin sensitization hazard

Strickland J, Zang Q, Paris M, Lehman DM, Kleinstreuer N, Allen D, Choksi N, et al. Multivariate models for prediction of human skin sensitization hazard. Poster presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

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Effects of nitrogen-doped and pristine multi-walled carbon nanotubes in human bronchial epithelial cells and lung fibroblasts

Mihalchik AL. Effects of nitrogen-doped and pristine multi-walled carbon nanotubes in human bronchial epithelial cells and lung fibroblasts. Presented at the Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

Understanding the relationship between alterations in thyroid hormone levels and subsequent neurodevelopmental impacts

Brown L, Pepping T, He K. Understanding the relationship between alterations in thyroid hormone levels and subsequent neurodevelopmental impacts. Poster presented at Society of Toxicology, New Orleans, LA, 2016.

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2015 (55 POSTS)

Machine learning approaches for predicting human skin sensitization hazard

Strickland J, Zang Q, Paris M, Kleinstreuer N, Lehmann DM, Allen D, Choksi N, et al. Machine learning approaches for predicting human skin sensitization hazard. Poster presented at FutureToxIII, Baltimore, MD, November 2015

Inhalation toxicology – Regulatory aspects for pharmaceuticals

Ulrich K. Inhalation toxicology – Regulatory aspects for pharmaceuticals. Presentation to In Vitro Toxicology Society Annual Meeting, Birmingham, UK, 2015.

Requirements of nonclinical inhalation studies for clinical development and registration

Ulrich, K. Requirements of nonclinical inhalation studies for clinical development and registration. Presentation to British Society of Toxicological Pathologists (BSTP) — Continuing Education Symposium 4, Department of Pathology, Cambridge, UK, 2015.

Historical comparator studies: Strengths, limitations, and analytical considerations in using historical pooled clinical data for evaluating efficacy and safety of new therapies

Kelsh MA, Chia VM. Historical comparator studies: Strengths, limitations, and analytical considerations in using historical pooled clinical data for evaluating efficacy and safety of new therapies. Presented at International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE) Boston, MA, August 25, 2015.

Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice

Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.

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Reduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling

Kirman CR, Proctor DM, Suh M, Hays S. Reduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.

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