Publications
William D. Klaren (56 POSTS)
2025 (4 POSTS)
Targeted state of the science scoping review for incorporating stress within experimental models of chemical toxicity
Klaren W. Targeted state of the science scoping review for incorporating stress within experimental models of chemical toxicity. Abstract 1260, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractIncorporating stress as a variable into toxicological testing: Advancing our understanding of cumulative impacts
Klaren W. Incorporating stress as a variable into toxicological testing: Advancing our understanding of cumulative impacts. Abstract 1259, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
View AbstractApplication of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response
Wikoff DS, Vincent MJ, Heintz MM, Pastula ST, Reichert H, Klaren WD, Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152. PMID: 39792025.
View AbstractAn integrated ecotoxicological study reliability framework for use in toxicity value development
Kennedy SB, Heintz MM, Klaren WD, Wikoff DS, Haws LC, Fitch SE. 2025. An integrated ecotoxicological study reliability framework for use in toxicity value development. Environ Tox Chem 44(4):1142-1153; doi: 10.1093/etojnl/vgaf030. PMID: 39873747.
View Abstract2024 (6 POSTS)
Exploring biomarker-based methods to incorporate non-chemical stressor exposures into cumulative assessments for potentially vulnerable population groups
East A, Klaren W, Covington T, Rish W. Exploring biomarker-based methods to incorporate non-chemical stressor exposures into cumulative assessments for potentially vulnerable population groups. International Society of Exposure Science, Montreal, Canada, October 2024.
View AbstractComparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044. PMID: 38574381.
View AbstractComparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes
Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045. PMID: 38574385.
View AbstractDevelopment and application of systematic approach to inventory and interrogate thyroid hormone network information
Lynn SG, Lea IA, Urban J, Borghoff SJ, Wikoff D, Fitch S, Perry C, Choksi N, Britt J, Heintz M, Klaren W, et al. Development and application of systematic approach to inventory and interrogate thyroid hormone network information. Abstract 4357, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractEvidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA
Thompson CM, Heintz MM, Rogers SI, Fitch SE, Rivera BN, Klaren WD, Vincent MJ, Wikoff DS, Haws LC. Evidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA. Abstract 3654, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View AbstractDelayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes
Heintz M, Klaren W, East A, Haws L, Thompson C. Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
View Abstract2023 (6 POSTS)
A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds
Ring C, Blanchette A, Klaren WD, Fitch S, Haws L, Wheeler MW, DeVito MJ, Walker N, Wikoff D. 2023. A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds. Regul Toxicol Pharmacol 143(11):105464; doi: 10.1016/j.yrtph.2023.105464. PMID: 37516304.
View AbstractIntegrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams
Cordova AC, Klaren WD, Ford LC, Grimm FA, Baker ES, Zhou YH, et al. 2023. Integrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams. Toxics 11(7):586; doi: 10.3390/toxics11070586. PMID: 37505552.
View AbstractScoping review of the immunomodulatory effects of cannabidiol: Effects within T cells.
Rivera BN, Svetlik A, Klaren WD, Wikoff DS, Henderson RG. Scoping review of the immunomodulatory effects of cannabidiol: Effects within T cells. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver
Klaren WD, Heintz MM, East AW, Thompson CM, Haws LC. In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors.
East A, Rish W, Klaren WD. Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame
Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.
View Abstract2022 (3 POSTS)
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays
House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelsegers HB, Gant TW, Wright FA, Rusyn I. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX 39(3):388-404; doi: 10.14573/altex.2107051. PMID: 35288757.
View AbstractReproduction and developmental toxicological evaluation of piperonyl butoxide (PBO)
Klaren WD, Hoberman AM, Hauswirth JW. Reproduction and developmental toxicological evaluation of piperonyl butoxide (PBO). Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.
View AbstractComparison of public and private literature databases for toxicological investigations
Fitch S, Klaren WD, LaPlaca S, Payne L, Wikoff D. Comparison of public and private literature databases for toxicological investigations. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.
View Abstract2021 (1 POST)
Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD, Harris MA, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18(May):100166; doi: 10.1016/j.comtox.2021.100166. PMID: 34013136.
View Abstract