Abstracts and Presentations (1104 POSTS)

2011 (40 POSTS)

VOC serum levels in the general U.S. population: An analysis of the 2003-2004 NHANES dataset

Fitzgerald LBurkhalter B, Urban J, Staskal D, Harris M, Haws L. VOC serum levels in the general U.S. population: An analysis of the 2003-2004 NHANES dataset. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011

View Abstract

Determining the mechanism of activation of glycoprotein VI

Hinerman J, Herr A. Determining the mechanism of activation of glycoprotein VI. Poster presented to the Ohio Valley Crystallographic Symposium Meeting, Cleveland, OH, November 2011.

Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water

Haws L, Proctor D, Thompson C, Harris M. Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Presented at  Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

Bioaccessibility-based read-across assessment of nickel compounds for oral systemic toxicity

Henderson RG, Cappellini D, Seilkop S, Oller A, Bates H. Bioaccessibility-based read-across assessment of nickel compounds for oral systemic toxicity. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

Comparison of basal and CrVI-mediated solute carrier gene expression in rodent duodenal epithelium

Kim S, Thompson CM, Kopec AK, Harris MA, Zacharewski TR. Comparison of basal and CrVI-mediated solute carrier gene expression in rodent duodenal epithelium. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

Use of mode of action and pharmacokinetic findings to inform the cancer risk assessment of ingested Cr(VI): A case study

Proctor D, Haws L, Thompson C, Harris M. 2011. Use of mode of action and pharmacokinetics to inform the cancer risk assessment of ingested Cr(VI): A case study. Presented at the Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

Using mode of action data to guide quantitative cancer risk assessment: A case study of hexavalent chromium in drinking water

Proctor D, Meek B. Using mode of action data to guide quantitative cancer risk assessment: A case study of hexavalent chromium in drinking water. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

Single nucleotide polymorphisms in the human aryl hydrocarbon receptor interacting protein (AIP) gene from six ethnic populations

Staskal-Wikoff D, Budinsky R, Rowlands JC. Single nucleotide polymorphisms in the human aryl hydrocarbon receptor interacting protein (AIP) gene from six ethnic populations. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.

View Abstract

2010 (25 POSTS)

Associations between platelet count and survival and disease progression in thrombocytopenic patients with myelodysplastic syndromes

Yong M, Kuehn C, Kelsh M, Mitchell M, et al. Associations between platelet count and survival and disease progression in thrombocytopenic patients with myelodysplastic syndromes. Presented at the American Society of Hematology, Orlando, FL, December 2010.

Genotoxic impurity guidance – Current experiences, FDA perspective

Robison TW. Genotoxic impurity guidance – Current experiences, FDA perspective. USP Annual Meeting, New Orleans, LA, December 2010.

Serum concentrations of dioxin-like compounds in a population in Midland, Michigan: An evaluation of the impact of soil exposures

Harris M, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Simon T, Haws L. Serum concentrations of dioxin-like compounds in a population in Midland, Michigan: An evaluation of the impact of soil exposures. Presented at Dioxin 2010, San Antonio, TX, September 2010.

Characterizing uncertainty and population variability in a PBPK-PD mathematical model for the oxime HI-6

Sterner TR, Ruark CD, Covington TR, Hack CE, Gearhart JM. Characterizing uncertainty and population variability in a PBPK-PD mathematical model for the oxime HI-6. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Orlando, FL, November 2010.

Route of entry model for predicting chemical warfare agent miosis

Makley M, Ruark C, Covington T, Robinson P, Gearhart J. Route of entry model for predicting chemical warfare agent miosis. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Orlando, FL, November 2010.

Exploring issues in simulating dermal exposure using a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model for VX

Covington T, Robinson P, Gearhart J. Exploring issues in simulating dermal exposure using a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model for VX. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Orlando, FL, November 2010.

Assessment of the impact of various soil cleanup levels on serum concentrations of dioxin-like compounds in humans

Harris M, Tachovsky JA, Staskal-Wikoff D, Simon T, Burkhalter B, Urban J, Haws L. 2010. Assessment of the impact of various soil cleanup levels on serum concentrations of dioxin-like compounds in humans. Presented at Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 2010.

Dealing with positive in vitro mammalian cell genotoxicity assays

Robison TW. Dealing with positive in vitro mammalian cell genotoxicity assays. IQPC Genotoxicity and Carcinogenicity Testing 2010 Conference, London, UK, October 2010.

Dealing with genotoxic impurities from a regulatory perspective

Robison TW. Dealing with genotoxic impurities from a regulatory perspective. IQPC Genotoxicity and Carcinogenicity Testing 2010 Conference, London, UK, October 2010.

Assessing genotoxic impurities

Robison TW. Assessing genotoxic impurities. DIA Meeting (Early drug development: Navigating the treacherous rapids). Bethesda, MD, October 2010

Biomonitoring – A tool for assessing community exposures to air toxics

Haws L. Biomonitoring – A tool for assessing community exposures to air toxics. Presented at the Air Quality 2010 Conference, University of Texas School of Law, November 2010.

An evaluation of the influence of different soil cleanup levels on the concentration of dioxin-like compounds in human serum

Haws L, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Urban J, Simon T, Harris M. An evaluation of the influence of different soil cleanup levels on the concentration of dioxin-like compounds in human serum. Presented at Dioxin 2010, San Antonio, TX, September 2010.