Publications
risk assessment (204 POSTS)
2019 (11 POSTS)
Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment
Clewell RA, Thompson CM, Clewell HJ. 2019. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chem Biol Interact 301(March):112–127; doi: 10.1016/j.cbi.2019.01.025.
View AbstractUse of the latest science in cancer risk assessment for hexavalent chromium: Is it time to step away from the default regulatory approaches?
Proctor D. Use of the latest science in cancer risk assessment for hexavalent chromium: Is it time to step away from the default regulatory approaches? Invited presentation to the International Union of Toxicology (IUTOX) / International Congress of Toxicology (ICT) meeting, Honolulu, HI, June 2019.
Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
Wikoff D, Haws L, Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol 39(9):1293-1310; doi: 10.1002/jat.3814.
View AbstractA fit-for-purpose framework for use of systematic methods in risk assessment
Wikoff D, Erranguntla N, Lewis J, Foreman J. A fit-for-purpose framework for use of systematic methods in risk assessment. Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.
Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3)
Borghoff S, Fitch S, Britt J, Franke K, Wikoff D. Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.
Potential airborne asbestos exposure and risk associated with the historical use of cosmetic talcum powder products
Burns AM, Barlow CA, Banducci AM, Unice KM, Sahmel J. 2019. Potential airborne asbestos exposure and risk associated with the historical use of cosmetic talcum powder products. Risk Anal 39(10):2272-2294; doi: 10.1111/risa.13312. PMID: 30980426.
View AbstractApplication of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count
Ring CL, Urban J, Wikoff D, Thompson C, Budinsky RA, Haws LC. Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
View AbstractQuantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysi
Wheeler MW, Piegorsch WW, Bailer AJ. 2019. Quantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysis. Risk Anal 39(3):616-29; doi: 10.1111/risa.13218. PMCID: PMC6408269
View AbstractAn updated evaluation of potential health hazards associated with exposures to asbestos-containing drywall accessory products
Jacobs NFB, Towle KM, Finley BL, Gaffney SH. 2019. An updated evaluation of potential health hazards associated with exposures to asbestos-containing drywall accessory products. Crit Rev Toxicol 49(5):430–444; doi: 10.1080/10408444.2019.1639612.
View AbstractBioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations
Suh M, Casteel S, Dunsmore M, Ring C, Verwiel A, Proctor DM. 2019. Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Sci Tot Environ 660(April 10):677–689; doi: 10.1016/j.scitotenv.2018.12.317.
View Abstract2018 (8 POSTS)
Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Wikoff D, Goodrum P, Haws L, Budinsky R. Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
View AbstractMoving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment
Wikoff D. Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
View AbstractCounting what matters: Combining robust assessment practices with dynamic visual dashboards.
Blanck J, Anton B, Price C, Woodson S, Seal S, Seymour A. Counting what matters: Combining robust assessment practices with dynamic visual dashboards. Presentation to the Medical Library Association (MLA) Annual Meeting and Exhibition, Atlanta, GA, 2018.
Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards
Proctor DM. Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards. Association of Environmental Health Sciences San Diego, CA, March 2018.
Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans
Thompson CT, Suh M, Chappell G, Borghoff S, Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor DM. 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189; doi: 10.1016/j.yrtph.2018.05.006.
View AbstractEvidence integration in risk assessment: The science of combining apples and oranges
Wikoff D (contributing author), EFSA (European Food Safety Authority), EBTC (Evidence-Based Toxicology Collaboration). 2018. EFSA Scientific Colloquium 23. Evidence integration in risk assessment: The science of combining apples and oranges. EFSA Supporting Publication 2018:15(3):1396; doi: 10.2903/sp.efsa.2018.EN-1396.
View AbstractRole of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene
Wikoff D, Urban JD, Harvey S, Haws LC. 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol 37(2):125-143; doi: 10.1177/1091581818754330.
View AbstractBounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water
Rish W, Pfau EJ. 2018. Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Risk Analysis 38(4):724-754; doi: 10.1111/risa.12884.
View Abstract2017 (10 POSTS)
Guidelines for performing systematic reviews in the development of toxicity factors
Schaefer HR, Myers, JL. 2017. Guidelines for performing systematic reviews in the development of toxicity factors. Regul Toxicol Pharmacol 91(Dec):124-141; doi: 10.1016/j.yrtph.2017.10.008. PMID: 29080853.
View AbstractBayesian hierarchical structure for quantifying population variability to inform probabilistic health risk assessments
Shao K, Allen BC, Wheeler MW. 2017. Bayesian hierarchical structure for quantifying population variability to inform probabilistic health risk assessments. Risk Anal 37(10):1865-78; doi: 10.1111/risa.12751.PMCID: PMC6151353.
View Abstract