Publications
modeling (132 POSTS)
2015 (6 POSTS)
Comparison of smoothing spline regression and conventional modeling approaches for quantitative risk assessments of human dioxin exposure
Thompson CM, Suh M, Hixon G, Bichteler A. Comparison of smoothing spline regression and conventional modeling approaches for quantitative risk sssessments of human dioxin exposure. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractUsing geographic information systems to model paths from remote villages to the nearest Bolivian health clinics
Reddick H., Schaefer, C. Using geographic information systems to model paths from remote villages to the nearest Bolivian health clinics. Texas Public Health Association, Austin, TX, 2015.
Evaluation of empirically-based PBPK modeling approaches for modeling ante- and post mortem ethanol concentrations in biological matrices
Cowan DM, Maskrey JR, Fung E, Woods T, Stabryla L, Scott PK, Finley BL. Evaluation of empirically-based PBPK modeling approaches for modeling ante- and post mortem ethanol concentrations in biological matrices. Poster presentation Society of Toxicology 54th Annual Meeting, San Diego, CA, 2015.
FutureTox II: In vitro data and in silico models for predictive toxicology
Knudsen TB, Keller DA, Sander M, Carney EW, Doerrer NG, Eaton DL, Fitzpatrick SC, Hastings KL, Mendrick DL, Tice RR, Watkins PB, Whelan M. 2015. FutureTox II: In vitro data and in silico models for predictive toxicology. Toxicol Sci 143(2):256–267; doi: 10.1093/toxsci/kfu234.
View Abstract2014 (4 POSTS)
Variation analysis of PBPK model parameters for describing the delivery of Cr(VI) to the small intestines of humans
Kirman CR, Proctor D, Suh M, Thompson CM, Harris MA, Haws LC, Hays SM. Variation analysis of PBPK model parameters for describing the delivery of Cr(VI) to the small intestines of humans. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
View AbstractSmoothing regression splines as the basis for dose-response modeling
Hixon JG, Thompson C, Bichteler A, Abraham L. Smoothing regression splines as the basis for dose-response modeling. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
View AbstractRefined biokinetic model for humans exposed to cobalt dietary supplements and other sources of systemic cobalt exposure
Unice KM, Kerger BD, Paustenbach DJ, Finley BL, Tvermoes BE. 2014. Refined biokinetic model for humans exposed to cobalt dietary supplements and other sources of systemic cobalt exposure. Chem-Biol Interact 216:53–74; doi: 10.1016/j.cbi.2014.04.001. PMID: 24726710.
View AbstractCorrelation of blood Cr(III) and adverse health effects: Application of PBPK modeling to determine non-toxic blood concentrations
Monnot AD, Christian WV, Paustenbach DJ, Finley BL. 2014. Correlation of blood Cr(III) and adverse health effects: Application of PBPK modeling to determine non-toxic blood concentrations. Crit Rev Toxicol 44(7):618–637; doi:10.3109/10408444.2014.926472. PMID: 25068491.
View Abstract2013 (5 POSTS)
Physiologically based pharmacokinetic model for humans orally exposed to chromium
Kirman CR, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM, Lin SS, Parker W, Hays SM. 2013. Physiologically based pharmacokinetic model for humans orally exposed to chromium. Chem Biol Interact 204(1):13-27; doi: 10.1016/j.cbi.2013.04.003.
View AbstractAn empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty
Wheeler MW, Bailer AJ. 2013. An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty. Regul Toxicol Pharmacol 67(1):75-82; doi: 10.1016/j.yrtph.2013.06.006. PMCID: PMC4724873
View AbstractDevelopment of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling
Thompson CM, Gaylor DW, Tachovsky JA, Perry C, Carakostas MC, Haws LC. 2013. Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. J Appl Toxicol 33(12):1395-1406; doi: 10.1002/jat.2799.
View AbstractUsing PBPK modeling to address diurnal variation and age differences in hexavalent chromium toxicokinetics in humans
Kirman CR, Thompson CM, Proctor DM, Suh M, Haws LC, Harris MA, Hays SM. Using PBPK modeling to address diurnal variation and age differences in hexavalent chromium toxicokinetics in humans. Presented at Society of Toxicology 52nd Annual Meeting,San Antonio, TX, March 2013.
View AbstractHuman lethality predictions from exposure to VX using a physiologically-based pharmacokinetic-pharmacodynamic model
Covington TR, Ruark CD, Yu KO, Gearhart JM. Human lethality predictions from exposure to VX using a physiologically-based pharmacokinetic-pharmacodynamic model. Poster presented at Society of Toxicology 52nd Annual Meeting, San Antonio, TX, March 2013.
2012 (6 POSTS)
Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium
Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM. 2012. Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact 200(1):45-64; doi: 10.1016/j.cbi.2012.08.016.
View AbstractCharacterisation of a mouse model of cigarette smoke extract-induced lung inflammation
Lamb DJ, Parker N, Ulrich K, Walsh R, Yeadon M, Evans SM. 2012. Characterisation of a mouse model of cigarette smoke extract-induced lung inflammation. J Pulmon Resp Med 2(3); doi: 10.4172/2161-105X.1000125.
View AbstractInorganic cobalt supplementation: Prediction of cobalt levels in whole blood and urine using a biokinetic model
Unice KM, Monnot AD, Gaffney SH, Tvermoes BE, Thuett KA, Paustenbach DJ, Finley BL. 2012. Inorganic cobalt supplementation: Prediction of cobalt levels in whole blood and urine using a biokinetic model. Food Chem Toxicol 50(7):2456–2461; doi: 10.106/j.fct.2012.04.009. PMID: 22538081.
View AbstractDose-response relationships for blood cobalt concentrations and health effects: A review of the literature and application of a biokinetic model
Finley BL, Monnot AD, Gaffney SH, Paustenbach DJ. 2012. Dose-response relationships for blood cobalt concentrations and health effects: A review of the literature and application of a biokinetic model. J Toxicol Environ Health B, 15(8):493–523; doi: 10.1080/10937404.2012.744287.
View AbstractA calibrated human PBPK model for benzene inhalation with urinary bladder and bone marrow compartments
Knutsen JS, Kerger BD, Finley BL, Paustenbach DJ. 2012. A calibrated human PBPK model for benzene inhalation with urinary bladder and bone marrow compartments. Risk Anal 33 (7):1237–1251; doi: 10.1111/j.1539-6924.2012.01927.x. PMID: 23278103.
View AbstractPhysiologically-based pharmacokinetic model for mice, rats and humans orally-exposed to chromium
Kirman CR, Hays SM, Aylward LL, Suh M, Proctor D. 2012. Physiologically-based pharmacokinetic model for mice, rats and humans orally-exposed to chromium. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
View Abstract2011 (3 POSTS)
Derivation of an oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling
Thompson C, Perry C, Gaylor D, Tachovsky A, Burkhalter B, Haws L. Derivation of an oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. Presented at Society of Toxicology 50th Annual Meeting, Washington DC, March 2011.
View Abstract