Publications
Susan Borghoff, M.S.P.H., Ph.D., DABT (73 POSTS)
2016 (8 POSTS)
The effects of a high fat (HF) diet on male diversity outbred (DO) mice
DeVito MJ, Borghoff SJ, Zorilla LM, Shockley K, Kissling G, Travlos G. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.
View AbstractA high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework
Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77(June):143-159. doi: 10.1016/j.yrtph.2016.01.018.
View AbstractDose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats
Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi: 10.1016/j.toxrep.2016.01.007.
View Abstract2015 (4 POSTS)
Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice
Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractIdentification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP)
Borghoff SJ, Wikoff D, White MC, Thompson C, Haws LC. Identification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP). Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractEvaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast
Wikoff D, White MC, Borghoff SJ, Haws LC. Evaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractMethyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding
Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicol 333(2015 July 3):1-13; doi: 10.1016/j.tox.2015.02.003.
View Abstract2014 (6 POSTS)
Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment
Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.
View AbstractMethyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-Globulin (a2u) nephropath in male but not female F344 rats
Borghoff SJ, Hard GC, Poet TS, Davis J, Green S, Hughes B, Mensing T, Sarang SS. Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-globulin (a2u) nephropath in male but not female F344 rats. Presented at the Society of Toxicology’s 53rd Annual Meeting, Phoenix, AZ, March 2014.
View AbstractDevelopment of non-cancer based toxicity factors and daily dose estimates for TBBPA
Haws LC, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Wikoff D. Development of non-cancer based toxicity factors and daily dose estimates for TBBPA. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
View AbstractSubchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC)
Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.
View AbstractLessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program
Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG and others. 2014. t4 Workshop report — Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Altex 31(1):63-78.
View AbstractDevelopment of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA
Wikoff D, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Haws LC. Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
View Abstract