Publications

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Susan Borghoff, M.S.P.H., Ph.D., DABT (73 POSTS)

2025 (9 POSTS)

Evaluation of an anti-thyroid mode of action for thyroid follicular cell adenomas in female mice exposed to tertiary butyl alcohol

Borghoff SJ, Heintz MM, Rivera BN, Haws L, Thompson C. 2025. Evaluation of an anti-thyroid mode of action for thyroid follicular cell adenomas in female mice exposed to tertiary butyl alcohol. Regul Toxicol Pharmacol 105936;  doi: 10.1016/j.yrtph.2025.105936. Online ahead of print Sept. 4, 2025. PMID: 40914479.

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Measurement of vinyl acetate monomer in consumer products and modeled estimates of consumer exposure

Gauthier A, Behymer W, Bare J, Kramer M, Barranco WT, Longtin JP, Borghoff S, Jaques A. 2025. Measurement of vinyl acetate monomer in consumer products and modeled estimates of consumer exposure. J Exp Sci Environ Epidemiol; doi: 10.1038/s41370-025-00786-y. Online ahead of print June 18, 2025. PMID: 40533479.

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Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton EK, Borghoff SJ. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

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Identifying structural overlap between EDSP universe of chemicals and ToxCast/Tox21 using chemical clustering and uniform manifold approximation and projection

Cook B, Nelms M, Harris D, Bever RJ, Lynn SG, Williams D, Borghoff S, Edwards SW, Markey K. Identifying structural overlap between EDSP universe of chemicals and ToxCast/Tox21 using chemical clustering and uniform manifold approximation and projection. Abstract 4034, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

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Evaluation of potential obesogenicity through a mode of action approach: A case study with MTBE

Buerger AN, Vincent MJ, Fitch S, Rushton EK, Borghoff SJ. Evaluation of potential obesogenicity through a mode of action approach: A case study with MTBE. Abstract 3928, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

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Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data

Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.

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Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate

Lea IA, Feifarek D, Mihalchik A, Heintz M, Haws L, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2025. Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate. Curr Res Toxicol 8:100221; doi: 10.1016/j.crtox.2025.100221. PMID: 40041033.

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Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data

Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.

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Evaluation of the endocrine disrupting potential of Di-isononyl phthalate

Lea IA, Buerger AN, Feifarek D, Mihalchik A, Heintz MM, Haws LC, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2025. Evaluation of the endocrine disrupting potential of Di-isononyl phthalate. Curr Res Toxicol 8:100220; doi: 10.1016/j.crtox.2025.100220. PMID: 40092461. Corrigendum 8:100233; doi: 10.1016/j.crtox.2025.100233; PMID 40529321.

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2024 (12 POSTS)

Clustering chemicals for predicting behavior and hazards: Insights from the endocrine disruptor screening program (EDSP) universe of chemicals

Cook B, Nelms MD, Harris D, Bever RJ, Lynn SC, Borghoff S, et al. Clustering chemicals for predicting behavior and hazards: Insights from the endocrine disruptor screening program (EDSP) universe of chemicals. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.

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Prediction of chemical suitability for screening in a high-throughput assay platform using an in silico mass balance model

Covington TR, Borghoff SJ, Bacigalupi L, O’Neal S, Cook B, Nelms M, et al. Prediction of chemical suitability for screening in a high-throughput assay platform using an in silico mass balance model. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.

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Leveraging computational tools for enhanced human-in-the-loop systematic literature reviews

Lea IA, Borghoff SJ, Chew R, Bell S, Edwards S, Vasko J, et al. Leveraging computational tools for enhanced human-in-the-loop systematic literature reviews. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.

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Categorizing articles for environmental health systematic evidence mapping: A zero-shot machine learning approach using large language models

Holt JR, Chew RF, Bunnage E, Lea I, Borghoff SJ, Sayer R, et al. Categorizing articles for environmental health systematic evidence mapping: A zero-shot machine learning approach using large language models. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.

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Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay

Thompson CM, Dewhurst N, Moundous D, Borghoff SJ, Haws LC, Vasquez MZ. 2024. Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay. Environ Mol Mutagen 65(3–4):129–136; doi: 10.1002/em.22601. PMID: 38717101.

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Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models

Nelms MD, Antonijevic T, Ring C, Harris DL, Bever RJ, Lynn SG, … Borghoff S, et al. 2024. Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models. Front Toxicol 6(April 17):1346767; https://doi.org/10.3389/ftox.2024.1346767. PMID: 38694816.

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Optimizing androgen receptor prioritization using high-throughput assay-based activity models

Edwards S, Antonijevic T, Nelms M, Ring C, Harris D,… Borghoff S, Markey K. Optimizing androgen receptor prioritization using high-throughput assay-based activity models. Abstract 4381, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

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Chemistry domain of applicability evaluation of estrogen receptor high-throughput assay-based activity models

Nelms M, Antonijevic T, Ring C, Harris D, Bever RJ,… Borghoff S, et al. Chemistry domain of applicability evaluation of estrogen receptor high-throughput assay-based activity models. Abstract 4380, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

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Development and application of systematic approach to inventory and interrogate thyroid hormone network information

Lynn SG, Lea IA, Urban J, Borghoff SJ, Wikoff D, Fitch S, Perry C, Choksi N, Britt J, Heintz M, Klaren W, et al. Development and application of systematic approach to inventory and interrogate thyroid hormone network information. Abstract 4357, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

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Evaluation of the endocrine disrupting potential of di-isononyl phthalate

Borghoff SJ, Feifarek D, Mihalchik A, Heintz M, Haws L, Nyambego H, Goyak K, Lea IA. Evaluation of the endocrine disrupting potential of di-isononyl phthalate. Abstract 3931, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024. 

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Evaluation of the endocrine disrupting potential of di-isodecyl phthalate

Lea IA, Feifarek D, Mihalchik A, Heintz M, Haws L, Nyambego H, Goyak K, Borghoff SJ. Evaluation of the endocrine disrupting potential of di-isodecyl phthalate. Abstract 3930, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

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