Publications
Toxicology (397 POSTS)
2017 (25 POSTS)
Failed dose formulation analysis during a GLP study — Now what?
Mease K, Kimzey A, Lansita J. Failed dose formulation analysis during a GLP study — Now what? Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.
View AbstractDerivation of an oral toxicity reference value for nickel
Haber LT, Bates HK, Allen BC, Vincent MJ, Oller AR. 2017. Derivation of an oral toxicity reference value for nickel. Regul Toxicol Pharmacol 87(S1–S18), doi: 10.1016/j.yrtph.2017.03.011.
View AbstractDevelopment of a curated database of in vivo developmental toxicity data
Ceger P, Choksi N, Hamm J, Truax J, Daniel A, Allen D, et al. Development of a curated database of in vivo developmental toxicity data. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.
View AbstractHost-microbiome responses to DEHP exposure: A multigenerational obesity study in Danio rerio.
Buerger AN, Schmidt J, Martyniuk CJ, Bisesi JH. Host-microbiome responses to DEHP exposure: A multigenerational obesity study in Danio rerio. Society of Environmental Toxicology and Chemistry North America Meeting, 2017.
Case studies for neurotoxic chemicals
Lynch M, Brown L, Chiger A. Case studies for neurotoxic chemicals. Presentation to Society for Risk Analysis, San Diego, CA, 2017.
Evaluation of therapeutics for advanced-stage heart failure and other severely-debilitating or life-threatening diseases
Prescott JS, Andrews PA, Baker RW, Bogdanffy MS, Fields FO, Keller DA, Lapadula DM, Mahoney NM, Paul DE, Platz SJ, Reese DM, Stoch SA, DeGeorge JJ. 2017. Evaluation of therapeutics for advanced-stage heart failure and other severely-debilitating or life-threatening diseases. Clin Pharmacol Ther 102(2):219–227, doi: 10.1002/cpt.730.
View AbstractNavigating tissue chips from development to dissemination: A pharmaceutical industry perspective
Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B. 2017. Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective. Exp Biol Med (Maywood) 242(16):1579–1585, doi: 10.1177/1535370217715441.
View AbstractCurrent nonclinical testing paradigm enables safe entry to first-in-human clinical trials: The IQ consortium nonclinical to clinical translational database
Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ. 2017. Current nonclinical testing paradigm enables safe entry to first-in-human clinical trials: The IQ consortium nonclinical to clinical translational database. Toxicol Appl Pharmacol 334:100–109, doi: 10.1016/j.taap.2017.09.006.
View Abstract2016 (30 POSTS)
Assessing potential endocrine disruption in largemouth bass from a PCB-contaminated reservoir in South Carolina
LaPlaca SB, Scott GI. Assessing potential endocrine disruption in largemouth bass from a PCB-contaminated reservoir in South Carolina. Poster presentation at the 37th annual meeting of the Society of Environmental Toxicology and Chemistry, North America Chapter, Orlando, FL, November 2016.
Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes
Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol, DOI 10.1002/jat.3412
View AbstractNotch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice
Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, … Kuang, S. 2016. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med 213(10):2019–2037.
View AbstractStage-specific effects of notch activation during skeletal myogenesis
Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, Wen Y, Zhou D, Freeman J, Kuang S. 2016. Stage-specific effects of notch activation during skeletal myogenesis. Elife 5:e17355.
View AbstractHigh-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells
Klaren WD, Iwata Y, Lebakken CS, Grimm FA, Rusyn I. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. College of Veterinary Medicine Graduate Student and Postdoc Research Symposium, Texas A&M University, 2016.
Metallothionein’s role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption
Klaren WD, Flor SS, Gibson-Corley KN, Ludewig G, Robertson LW. 2016. Metallothionein’s role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicol Rep 3:21–28. PMID: 26770886.
View AbstractDiscovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K, et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372. PMID: 26709102.
View AbstractDiscovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu C, Kar NF, Li B, Costa M, Dingley KH, Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030. PMID: 26590100.
View AbstractBest-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations
Cowan DM, Maskrey JR, Fung ES, Woods TA, Stabryla LM, Scott PK, Finley BL. 2016. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul Toxicol Pharmacol 78:24–36.
View AbstractComment on flavoring chemicals in e-cigarettes: Diacetyl, 2,-3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes
Pierce JS, Abelmann A, Finley BL. 2016. Comment on flavoring chemicals in e-cigarettes: Diacetyl, 2,-3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes. Environ Health Persp 124(6):A100–A101.
View AbstractA preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay
Tvermoes BE, Unice KM, Winans B, Kovochich M, Christian WV, Donovan E, Fung ES, Finley BL, Kimber I, Paustenbach DJ. 2016. A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay. Toxicol Appl Pharmacol 308:77–90; doi: 10.1016/j.taap.2016.07.020.
View AbstractAssessment of indoor formaldehyde concentrations following the installation and removal of laminate flooring
Pierce JS, Abelmann A, Ruestow PS, Lotter J, Beckett E, Fritz HA, Bare JL, Unice KM. 2016. Assessment of indoor formaldehyde concentrations following the installation and removal of laminate flooring. Abstract #1689. Poster Presentation at Society of Toxicology (SOT) Annual Meeting, New Orleans, LA, March 2016.
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