Publications
Toxicology (397 POSTS)
2020 (27 POSTS)
Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia
Gentry R, Thompson CM, Franzen A, Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.
View AbstractDeveloping a health impact model for adult lead exposure and cardiovascular disease mortality
Brown L, Lynch M, Belova A, Klein R, Chiger A. 2020. Developing a health impact model for adult lead exposure and cardiovascular disease mortality. Environ Health Persp 128:9, https://doi.org/10.1289/EHP6552.
View AbstractLiver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry
Baudy AR, Otieno MA, Hewitt P, Gan J, Roth A, Keller D, Sura R, Van Vleet TR, Proctor WR. 2020. Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry. Lab Chip 20(2):215–225, doi: 10.1039/c9lc00768g.
View AbstractNext-generation DILI biomarkers: Prioritization of biomarkers for qualification and best practices for biospecimen collection in drug development
Roth SE, Avigan MI, Bourdet D, Brott D, Church R, Dash A, Keller D, Sherratt P, Watkins PB, Westcott-Baker L, Lentini S, Merz M, Ramaiah L, Ramaiah SK, Stanley AM, Marcinak J. 2020. Next-generation DILI biomarkers: Prioritization of biomarkers for qualification and best practices for biospecimen collection in drug development. Clin Pharmacol Ther 107(2):333–346, doi: 10.1002/cpt.1571.
View AbstractA pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies
Phillips JA, Grandhi TSP, Davis M, Gautier, J-C, Hariparsad N, Keller D, Sura R, Van Vleet TR. 2020. A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies. Lab Chip 20(3):468–476, doi: 10.1039/c9lc00925f.
View AbstractDeveloping in vitro assays to transform gastrointestinal safety assessment: Potential for microphysiological systems
Peters MF, Choy AL, Pin C, Leishman DJ, Moisan A, Ewart L, Guzzie-Peck PJ, Sura R, Keller DA, Scott CW, Kolaja KL. 2020. Developing in vitro assays to transform gastrointestinal safety assessment: Potential for microphysiological systems. Lab Chip 20(7):1177–1190, doi: 10.1039/c9lc01107b.
View AbstractHairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain
Liu S, Refaei M, Liu S, Decker A, Hinerman JM, Herr AB, Howell M, Musier-Forsyth K, Tsang P. 2020. Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain. J Biol Chem 295(34):12071–12085.
View Abstract2019 (28 POSTS)
Managing immunogenicity in the absence of an ADA assay is no monkey business (case study)
Mease K. Managing immunogenicity in the absence of an ADA assay is no monkey business (case study). Presentation at 25th annual Charles River Biotech Symposium, Carlsbad, CA, September 2019.
View AbstractIdentifying attributes that influence in vitro-to-in vivo concordance by comparing Tox21 bioactivity versus DrugMatrix transcriptomic responses across 130 chemicals
Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE. 2019. Identifying attributes that influence in vitro-to-in vivo concordance by comparing Tox21 bioactivity versus DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci 167(1):157–171; doi: 10.1093/toxsci/kfy220. PMID: 30202884.
View AbstractThree-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD)
Urban J, Wikoff D, Haws L. Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine. Washington, DC, June 2019.
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis
Heintz MM, Kumar R, Rutledge M, Baldwin WS. 2019. Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. J Nutr Biochem 70(August):125–137; doi: 10.1016/j.jnutbio.2019.05.004.
View AbstractCyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq
Heintz MM, Kumar R, Baldwin WS. Cyp2b-null male mice are susceptible to high-fat diet-induced obesity due to changes in PUFA metabolism and response to hepatic lipids as measured by RNAseq. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.
Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism
Olack E, Heintz MM, Baldwin WS. Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.
Triclosan exposure represses development and alters sphingomyelin metabolism in Daphnia magna as determined by RNA-seq and lipidomics
Heintz MM, Sengupta N, Noorai R, Baldwin WS. Triclosan exposure represses development and alters sphingomyelin metabolism in Daphnia magna as determined by RNA-seq and lipidomics. 20th Pollutant Responses in Marine Organisms, PRIMO20, Charleston, SC, May 2019.
The role of Cyp2b in diet-induced nonalcoholic steatohepatitis
Heintz MM, McRee R, Baldwin WS. The role of Cyp2b in diet-induced nonalcoholic steatohepatitis. Invited speaker: Clemson University Environmental Toxicology Program Seminar, Clemson, SC, April 2019.
Confocal laser scanning microscopy of morphology and apoptosis in organogenesis-stage mouse embryos
Zucker RM, Rogers JM. 2019. Confocal laser scanning microscopy of morphology and apoptosis in organogenesis-stage mouse embryos. Meth Mol Biol 1965:297–311; doi: 10.1007/978-1-4939-9182-2_20.
View AbstractSimulating a virtual high-performance aircraft pilot using physiologically-based pharmacokinetic modeling
Covington TR, Ott DK, Gearhart JM, Pangburn HA. Simulating a virtual high-performance aircraft pilot using physiologically-based pharmacokinetic modeling. Poster presented at Annual Meeting of the Aerospace Medical Association, Las Vegas, NV, May 2019.
Screening air dispersion modeling approach: Prop 65 community exposure assessments for industrial emitters
Bare JL, Novick RM, Maskrey JR, Unice KM. Screening air dispersion modeling approach: Prop 65 community exposure assessments for industrial emitters. Platform Presentation at Air and Waste Management Association’s (AWMA) Annual Conference and Exhibition: Conference Proceedings, Quebec City, Quebec, June 2019.
Qualitative review of recent USEPA TSCA occupational inhalation exposure assessments: Recommendations for future assessments
Bare JL, Maskrey JR, Hallett LA, Hamaji CM, Unice KM. 2019. Qualitative review of recent USEPA TSCA occupational inhalation exposure assessments: Recommendations for future assessments. Abstract P.122. Poster Presentation at Society for Risk Analysis (SRA) Annual Meeting, Arlington, VA, December 2019.
Identification and toxicity of compounds associated with tire wear particles in fathead minnow and mummichog
LaPlaca SB. Identification and toxicity of compounds associated with tire wear particles in fathead minnow and mummichog. Platform presentation at Pollutant Response in Marine Organism (PRIMO) symposium, Charleston, SC, May 2019.