Toxicology (397 POSTS)

2005 (18 POSTS)

Mechanisms of chemically-induced ocular injury and recovery: Current understanding and knowledge gaps

Stokes WS, Choksi NY, Allen DG, Truax JF, Tice RR, Eskes C, et al. Mechanisms of chemically-induced ocular injury and recovery: Current understanding and knowledge gaps. Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 2005.

Current in vitro models of ocular injury and recovery: Vascular assays

Choksi NY. Current in vitro models of ocular injury and recovery: Vascular assays. Presented at the ICCVAM/NICEATM/ECVAM Ocular Toxicity Scientific Symposium on Mechanisms of Chemically-Induced Ocular Injury and Recovery, May 2005

Issues in the use of PBPK modeling in the development of cancer slope factors for perchloroethylene

Kester JE, Gentry P, Covington TR, Clewell HJ. Issues in the use of PBPK modeling in the development of cancer slope factors for perchloroethylene. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 2005.

Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity

Kim DJ, Murray I, Burns AM, Gonzalez FJ, Perdew GH, Peters JM. 2005. Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. J Biol Chem 280(10):9519-9527; doi: 10.1074/jbc.M413808200. PMID: 15632134.

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Validation status of the Isolated Rabbit Eye (IRE) test method

Truax JF, Choksi NY, Inhof CJ, Allen DG, Tice RR, Stokes WS. Validation status of the Isolated Rabbit Eye (IRE) test method. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005

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Validation status of the Isolated Chicken Eye (ICE) test method

Allen DG, Choksi NY, Inhof CJ, Truax JF, Tice RR, Stokes WS. Validation status of the Isolated Chicken Eye (ICE) test method. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

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Validation status of the Bovine Corneal Opacity and Permeability (BCOP) test method

Inhof CJ, Choksi NY, Allen DG, Truax JF, Tice RR, Stokes WS. Validation status of the Bovine Corneal Opacity and Permeability (BCOP) test method. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

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Validation status of the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) test method

Choksi NY, Allen DG, Inhof CJ, Truax JF, Tice RR, Stokes WS. Validation status of the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) test method. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

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The performance characteristics of the in vivo rabbit eye test

Haseman JH, Choksi NY, Inhof CJ, Truax JF, Tice RR, Stokes WS. The performance characteristics of the in vivo rabbit eye test. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005

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Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis

Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. 2005. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26(1):219-227; doi: 10.1093/carcin/bgh285. PMID: 15447978.

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Characterization of the N27 dopaminergic cell line as a model for elucidating the actions of functionally selective dopaminergic ligands

Urban JD, Mailman RB. Characterization of the N27 dopaminergic cell line as a model for elucidating the actions of functionally selective dopaminergic ligands. 35th Annual Neuroscience Meeting, Washington, DC, November 2005.

2004 (7 POSTS)

Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors

Thompson CM, Wojno H, Greiner E, May EL, Rice KC, Selley DE. 2004. Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors. J Pharmacol Exper Therapeut 308(2):547–554; PMID: 14600248.

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Physiologically based pharmacokinetic modeling of arsenic in the mouse

Gentry PR, Covington TR, Mann S, Shipp AM, Yager JW, Clewell HJ III. 2004. Physiologically based pharmacokinetic modeling of arsenic in the mouse. J Toxicol Environ Health A 67:43–71.

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Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture

Degitz SJ, Rogers JM, Zucker RM, Hunter ES III. 2004. Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture. Birth Defects Res A 70(4):179–184; doi: 10.1002/bdra.20009.

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Pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice

Degitz SJ, Zucker RM, Kawanishi CY, Massenburg GS, Rogers JM. 2004. Pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice. Birth Defects Res A 70(4):172–178; doi: 10.1002/bdra.20010.

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Dose-dependent transitions in mechanisms of toxicity

Slikker W Jr., Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol 201(3):203–225; doi:10.1016/j.taap.2004.06.019.

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Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella

Lea IA, Widgren EE, O’Rand MG. 2004. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Reprod Biol Endocrinol 2(Jul 16):57; doi: 10.1186/1477-7827-2-57.

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Estimation of the underprediction rates for the in vivo rabbit dermal irritation assay

Choksi NY, Haseman JH, Allen DG, Tice RR, Stokes WS. Estimation of the underprediction rates for the in vivo rabbit dermal irritation assay. Poster presented at Society of Toxicology 43rd Annual Meeting, Baltimore, MD, March 2004.

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2003 (11 POSTS)

A comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES

Staskal DF, DeVito MJ, Ross DG, Birnbaum LS. A comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES, Society of Toxicology 42nd Annual Meeting, Salt Lake City, UT, 2003.

Risk perception: The reoccupancy of Lower Manhattan office space following the national tragedies of September 11, 2001

Panko JM, Shay EC, Unice KM. Risk perception: The reoccupancy of Lower Manhattan office space following the national tragedies of September 11, 2001. Poster at the Society for Risk Analysis Annual Conference, December 2003.