Publications
Toxicology (397 POSTS)
2015 (16 POSTS)
Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice
Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractPCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Society of Toxicology, Central States Regional Chapter Annual Meeting, Kansas City, KS, 2015.
PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Superfund Annual Meeting, San Juan, Puerto Rico, 2015.
Evaluation of leachate from tire and road wear particles (TRWP) upflow percolation column tests
Unice KM, Bare JL, Kreider ML, Panko JM. Evaluation of leachate from tire and road wear particles (TRWP) upflow percolation column tests. Poster at Society of Environmental Toxicology and Chemistry, 36th Annual Meeting, Salt Lake City, UT, November 1–5, 2015.
Naturally occurring diacetyl and 2,3-pentanedione concentrations associated with roasting and grinding unflavored coffee beans in a commercial setting
Gaffney SH, Abelmann A, Pierce JS, Glynn ME, Henshaw JL, McCarthy LA, Lotter JT, Liong M, Finley BL. 2015. Naturally occurring diacetyl and 2,3-pentanedione concentrations associated with roasting and grinding unflavored coffee beans in a commercial setting. Toxicol Rep 2:1171–1181.
View AbstractA robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats
Young RR, Thompson CM, Dinesdurage HR, Elbekai RH, Suh M, Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56(7):629-636; doi: 10.1002/em.21951.
View AbstractMethyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding
Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicol 333(2015 July 3):1-13; doi: 10.1016/j.tox.2015.02.003.
View AbstractEndocrine disrupting compounds alter risk-taking behavior in guppies (Poecilia reticulata)
Heintz MM, Brander SM, White JW. 2015. Endocrine disrupting compounds alter risk-taking behavior in guppies (Poecilia reticulata). Ethology 121(5):480–491; doi: 10.1111/eth.12362.
View AbstractEvaluation of leachate from tire and road wear particles (TRWP) upflow percolation column tests
Unice KM, Bare JL, Kreider ML, Panko JM. 2015. Evaluation of leachate from tire and road wear particles (TRWP) upflow percolation column tests. Poster Presentation at Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting, Salt Lake City, UT, November 2015.
Global cross-company data-sharing on the housing of non-rodents during the recording of cardiovascular telemetry data on safety pharmacology and toxicology studies
Bottomley A, Prior H, Cordes J. Global cross-company data-sharing on the housing of non-rodents during the recording of cardiovascular telemetry data on safety pharmacology and toxicology studies. Poster presented at Safety Pharmacology Society, Prague, September 2015.
Detection of mild and reversible neurohistopathological changes in the brain of juvenile (preweaned) beagle dogs treated with vigabatrin for up to 91 days
Bottomley AL, Rowles A, Mitchell DJ, Rasmussen AD. 2015. Detection of mild and reversible neurohistopathological changes in the brain of juvenile (preweaned) beagle dogs treated with vigabatrin for up to 91 days. Toxicol Pathol 43(7).
View AbstractIn silico predictions of skin sensitization using oecd qsar toolbox
Strickland J, Choksi NY, Allen DG, Casey W. In silico predictions of skin sensitization using oecd qsar toolbox. Poster presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractHTS and SAR analysis of chemicals from the elk river spill
Auerbach SS, Choksi NY, Ferguson S, Hsieh J, Svboda DL, Myatt GJ, et al. HTS and SAR analysis of chemicals from the elk river spill. Poster presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View AbstractClinical and nonclinical adverse effects of kinase inhibitors
Keller DA, Brennan RJ, Leach KL. 2015. Clinical and nonclinical adverse effects of kinase inhibitors. In: Urban L, Patel V, Vaz RJ (eds), Antitargets and Drug Safety, pp. 365–400. Wiley, doi: 10.1002/9783527673643.ch16.
2014 (21 POSTS)
Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment
Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.
View AbstractPersistent organic pollutants
Fitzgerald L, Wikoff DS. 2014. Persistent organic pollutants. In: Wexler P (Ed.), Encyclopedia of Toxicology, 3rd edition, vol 3. Elsevier, Inc., Academic Press, pp. 820-825.
Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-Globulin (a2u) nephropath in male but not female F344 rats
Borghoff SJ, Hard GC, Poet TS, Davis J, Green S, Hughes B, Mensing T, Sarang SS. Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-globulin (a2u) nephropath in male but not female F344 rats. Presented at the Society of Toxicology’s 53rd Annual Meeting, Phoenix, AZ, March 2014.
View AbstractNovel dose-dependent alterations in excitatory GABA during embryonic development associated with lead (Pb) neurotoxicity
Wirbisky SE, Weber GJ, Lee JW, Cannon JR, Freeman JL. 2014. Novel dose-dependent alterations in excitatory GABA during embryonic development associated with lead (Pb) neurotoxicity. Toxicol Lett 229:1–8.
View AbstractChemical selection tools analysis project and results
Panko JM. Chemical selection tools analysis project and results. Presented at GlobalChem. Global Chemical Regulations Conference, Baltimore, MD, March 2014.
Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC)
Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.
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