Publications
modeling (132 POSTS)
2019 (6 POSTS)
Assessing children’s exposure to manganese in drinking water using a PBPK model
Yoon M, Ring C, Van Landingham CB, Suh M, Song G, Antonijevic T, Gentry PR, Taylor MD, Keen AM, Andersen ME, Clewell JH. 2019. Assessing children’s exposure to manganese in drinking water using a PBPK model. Toxicol Appl Pharmacol 380(Oct 1):114695; doi: 10.1016/j.taap.2019.114695.
View AbstractCharacterizing export of land-based microplastics to the estuary – Part II: Sensitivity analysis of an integrated geospatial microplastic transport modeling assessment of tire and road wear particles
Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary – Part II: Sensitivity analysis of an integrated geospatial microplastic transport modeling assessment of tire and road wear particles. Sci Tot Environ 646(Jan 1):1650–1659; doi: 10.1016/j.scitotenv.2018.08.301.
View AbstractCharacterizing export of land-based microplastics to the estuary — Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed
Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary — Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed. Sci Tot Environ 646(Jan 1):1639–1649; doi: 10.1016/j.scitotenv.2018.07.368.
View AbstractAir dispersion modeling for historical community exposure reconstruction: An evaluation of the approach and its uncertainties
Scott PK, Abramson MM, Bare JL, Barlow CA. 2019. Air dispersion modeling for historical community exposure reconstruction: An evaluation of the approach and its uncertainties. EM-Mag Environ Mgrs January.
View AbstractBayesian additive adaptive basis tensor product models for modeling high dimensional surfaces: An application to high-throughput toxicity testing
Wheeler MW. 2019. Bayesian additive adaptive basis tensor product models for modeling high dimensional surfaces: An application to high-throughput toxicity testing. Biometrics 75(1):193-201; doi: 10.1111/biom.12942. PMCID: PMC6363906.
View AbstractMixture-based modeling of chemical ocular toxicity based on the US EPA hazard categories
Sedykh A, Choksi N, Allen D, Kleinstreuer N, Casey W, Shah R. Mixture-based modeling of chemical ocular toxicity based on the US EPA hazard categories. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019
View Abstract2018 (4 POSTS)
Evaluation and optimization of pharmacokinetic models for in vitro to in vivo extrapolation of estrogenic activity for environmental chemicals
Casey WM, Chang X, Allen DG, Ceger PC, Choksi NY, Hsieh JH, et al. 2018. Evaluation and optimization of pharmacokinetic models for in vitro to in vivo extrapolation of estrogenic activity for environmental chemicals. Environ Health Perspect 126(9):97001; doi: 10.1289/EHP1655.
View AbstractEvaluation of the uncertainties associated with the use of air dispersion modeling to estimate historical community exposure from manufacturers of asbestos-containing products
Abramson MM, Bare JL, Barlow CA, Scott PK. 2018. Evaluation of the uncertainties associated with the use of air dispersion modeling to estimate historical community exposure from manufacturers of asbestos-containing products. Platform Presentation at Air and Waste Management Association’s (AWMA) Annual Conference and Exhibition: Conference Proceedings, Hartford, CT, June 2018.
Development of a physiologically-based pharmacokinetic model for the virtual high-performance aircraft pilot
Covington TR, Ott DK, Gearhart JM, Pangburn HA. Development of a physiologically-based pharmacokinetic model for the virtual high-performance aircraft pilot. Poster presented at Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
Benchmark dose (BMD) modeling: Current practice, issues, and challenges
Haber LT, Dourson ML, Allen BC, Hertzberg RC, Parker A, Vincent MJ, et al. 2018. Benchmark dose (BMD) modeling: Current practice, issues, and challenges. Crit Rev Toxicol 48(5):387–415; doi: 10.1080/10408444.2018.1430121.
View Abstract2017 (6 POSTS)
Use of air dispersion modeling to estimate historical community exposure from manufacturers of asbestos-containing products
Bare JL, Abramson MM, Barlow CA, Scott PK. 2017. Use of air dispersion modeling to estimate historical community exposure from manufacturers of asbestos-containing products. Abstract P.96, Society for Risk Analysis (SRA) Annual Meeting, Arlington, VA, December 2017.
Bayesian quantile impairment threshold benchmark dose estimation for continuous endpoints
Wheeler MW, Bailer AJ, Cole T, Park RM, Shao K. 2017. Bayesian quantile impairment threshold benchmark dose estimation for continuous endpoints. Risk Anal 37(11):2107-18; doi: 10.1111/risa.12762. PMCID: PMC5740488.
View AbstractImproved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations
Kirman CR, Suh M, Proctor DM, Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325(15 June):9-17; doi: 10.1016/j.taap.2017.03.023.
View AbstractEthyl tertiary butyl ether (ETBE) and tertiary butyl alcohol (TBA) physiologically based pharmacokinetic (PBPK) model in rats: Contribution of binding to 2u-globulin and non-linear kinetics to kidney and liver responses in rats
Borghoff SJ, Ring C, Banton MI, Leavens TL. Ethyl tertiary butyl ether (ETBE) and tertiary butyl alcohol (TBA) physiologically based pharmacokinetic (PBPK) model in rats: Contribution of binding to 2u-globulin and non-linear kinetics to kidney and liver responses in rats. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.
View AbstractUsing physiologically-based pharmacokinetic modeling to address potentially sensitive subpopulations exposure to hexavalent chromium
Kirman CR, Proctor D, Suh M, Haws L, Harris M, Thompson C, Hays S. Using physiologically based pharmacokinetic modeling to address potentially sensitive subpopulations exposed to hexavalent chromium. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.
View AbstractEstimated inter-individual variations in high-performance aircraft pilot exposures using physiologically-based pharmacokinetic (PBPK) modeling and Monte Carlo analysis
Covington TR, Pangburn HA, Mayes RS, Ott DK, Gearhart JM. Estimated inter-individual variations in high-performance aircraft pilot exposures using physiologically-based pharmacokinetic (PBPK) modeling and Monte Carlo analysis. Poster presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.
2016 (2 POSTS)
Benchmark dose modeling for respiratory irritation from 2,3-pentanedione exposure
Cyrs WD, Dussex D, Glynn M, Finley BL. Benchmark dose modeling for respiratory irritation from 2,3-pentanedione exposure. Podium presentation at American Industrial Hygiene Conference & Exposition (AIHce), 2016.
Human equivalent concentrations for diacetyl based on minimal bronchiolar respiratory effects observed in animals: A refined analysis using current toxicology data and dosimetry models
Glynn ME, Adams RE, Beckett EM, Scott PK, Pierce JS, Finley BL. Human equivalent concentrations for diacetyl based on minimal bronchiolar respiratory effects observed in animals: A refined analysis using current toxicology data and dosimetry models. Abstract #1300. Poster presentation at Society of Toxicology 55th Annual Meeting, New Orleans, LA, 2016.
2015 (6 POSTS)
Historical context and recent advances in exposure-response estimation for deriving occupational exposure limits
Wheeler MW, Park R, Bailer A, Whittaker C. 2015. Historical context and recent advances in exposure-response estimation for deriving occupational exposure limits. J Occup Environ Hyg 12(sup1):S7-S17; doi: 10.1080/15459624.2015.1076934. PMCID: PMC4685605.
View AbstractReduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling
Kirman CR, Proctor DM, Suh M, Hays S. Reduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.
View Abstract