Publications

Alexander East (18 POSTS)

2025 (3 POSTS)

Artificial intelligence application to critical appraisal of published literature: A case example using the Criteria for Reporting and Evaluating Ecotoxicity Data (CRED) evaluation method

East A, Wheeler M, Kennedy S. Artificial intelligence application to critical appraisal of published literature: A case example using the Criteria for Reporting and Evaluating Ecotoxicity Data (CRED) evaluation method. Poster presentation, Health and Environmental Sciences Institute (HESI) Biannual Meeting, Washington, DC, June 2025.

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Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Pparα-null mouse livers

Heintz MM, Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM. 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Pparα-null mouse livers. Toxicol Sci 206(1):183-201; doi: 10.1093/toxsci/kfaf049. PMID: 40216583.

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Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice

Heintz MM, Buerger AN, Haws LC, East AW, Cullen JM, Thompson CM. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice. Abstract 3972, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025

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2024 (3 POSTS)

Exploring biomarker-based methods to incorporate non-chemical stressor exposures into cumulative assessments for potentially vulnerable population groups

East A, Klaren W, Covington T, Rish W. Exploring biomarker-based methods to incorporate non-chemical stressor exposures into cumulative assessments for potentially vulnerable population groups. International Society of Exposure Science, Montreal, Canada, October 2024.

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Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes

Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044. PMID: 38574381.

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Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes

Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045. PMID: 38574385.

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2023 (4 POSTS)

Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model

East A, Egeghy PP, Cohen Hubal EA, Slover R, Vallero DA. 2023. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. J Expos Sci Environ Epidemiol 33(1):56-68; doi: 10.1038/s41370-021-00374-w. PMID: 34373583.

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In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver

Klaren WD, Heintz MM, East AW, Thompson CM, Haws LC. In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.

Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors.

East A, Rish W, Klaren WD. Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.

A scoping assessment of implemented toxicokinetic models of per- and polyfluoro-alkyl substances, with a focus on one-compartment models

East A, Dawson DE, Brady S, Vallero DA, Tornero-Velez R. 2023. A scoping assessment of implemented toxicokinetic models of per- and polyfluoro-alkyl substances, with a focus on one-compartment models. Toxics 11(2):163; doi: 10.3390/toxics11020163. PMID: 36851038.

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2022 (3 POSTS)

The role of product use scheduler for estimating exposure to methyl, ethyl, propyl, and butyl parabenzoic acid (parabens) within the Combined Human Exposure Model

Dalton C, East A, Price P, Vallero D. The role of product use scheduler for estimating exposure to methyl, ethyl, propyl, and butyl parabenzoic acid (parabens) within the Combined Human Exposure Model. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022; doi: 10.23645/epacomptox.1934935.

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Using systematic evidence mapping to track the development of toxicokinetic models of PFAS from 2000–2021

Tornero-Velez R, Dawson D, East A, Breen M, Brady S, Vallero D, Hubal EC, Wambaugh, J. Using systematic evidence mapping to track the development of toxicokinetic models of PFAS from 2000–2021. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022; doi: 10.23645/epacomptox.19333283.

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Estimating exposure across chemical, individual, and media using sparse summary statistics with the Lorber-Egeghy-East Method R Package

East A, Dalton C, Egeghy P, Vallero D. Estimating exposure across chemical, individual, and media using sparse summary statistics with the Lorber-Egeghy-East Method R Package. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022; doi: 10.23645/epacomptox.20110814.

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2021 (4 POSTS)

Application of the Residential Population Generator (RPGen) in prediction of exposure outcomes for owners and renters from consumer products using the Combined Human Exposure Model (CHEM)

East A, Isaacs K, Vallero D. Application of the Residential Population Generator (RPGen) in prediction of exposure outcomes for owners and renters from consumer products using the Combined Human Exposure Model (CHEM). Symposium presented at International Society of Exposure Science Annual Meeting, Virtual, September 2021; doi: 10.23645/epacomptox.16632319.

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The role of the Product Use Scheduler (PUS) in determining product use categories (PUCs) for owners and renters in the Combined Human Exposure Model (CHEM)

East A, Brady S, Isaacs K, Vallero D. The role of the Product Use Scheduler (PUS) in determining product use categories (PUCs) for owners and renters in the Combined Human Exposure Model (CHEM). Symposium presented at International Society of Exposure Science Annual Meeting, virtual, September 2021; doi: 10.23645/epacomptox.16632271.

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Estimating longitudinal aggregate exposure — The third module of CHEM: Source to dose

Fisher H, East A, Vallero D. Estimating longitudinal aggregate exposure — The third module of CHEM: Source to dose. Symposium presented at International Society of Exposure Science Annual Meeting, virtual conference, September 2021; doi: 10.23645/epacomptox.16630675.

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The Residential Population Generator (RPGen): Parameterization of residential, demographic, and physiological data to model intraindividual exposure, dose, and risk

East A, Dawson D, Glen G, Isaacs K, Dionisio K, Price PS, et al. 2021. The Residential Population Generator (RPGen): Parameterization of residential, demographic, and physiological data to model intraindividual exposure, dose, and risk. Toxics 9(11):303; doi: 10.3390/toxics9110303.

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2020 (1 POST)

The Residential Population Generator (RPGen): Parameterization of residential, demographic, and physiological data to model intraindividual exposure, dose, and risk

East A, Price P, Dawson D, Glen G, Dionisio K, Isaacs K, Hubal EC, Vallero D. The Residential Population Generator (RPGen): Parameterization of residential, demographic, and physiological data to model intraindividual exposure, dose, and risk (presentation). Poster presented at Society of Environmental Toxicology and Chemistry North America 41st Annual Meeting, virtual conference, 2020. doi: 10.23645/epacomptox.13476864.

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