Publications
modeling (132 POSTS)
2011 (3 POSTS)
Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF
Wikoff DS, Thompson C, Walker N, DeVito M, Harris M, Birnbaum L, Haws L. Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF. Presented at Dioxin 2011, Brussels, Belgium, August 2011.
Exploring issues in simulating dermal exposure using a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model for VX
Covington T, Robinson P, Gearhart J. Exploring issues in simulating dermal exposure using a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model for VX. Poster presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.
2010 (1 POST)
Physiological parameters and databases for PBPK modeling
Johns DO, Owens EO, Thompson CM, Sonawane B, Hattis D, Krishnan K. 2010. Physiological parameters and databases for PBPK modeling. Chapter 5 in: Quantitative Modeling in Toxicology. Krishnan K, Andersen M (eds.). Wiley, p. 107.
View Abstract2009 (2 POSTS)
Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological parameters for healthy and health-impaired elderly
Thompson CM, Johns DO, Sonawane S, Barton HA, Hattis D, Tardif R, Krishnan K. 2009. Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological parameters for healthy and health-impaired elderly. J Toxicol Environ Health B 12(1):1–24; doi: 10.1080/10937400802545060.
View AbstractComparing model averaging with other model selection strategies for benchmark dose estimation
Wheeler MW, Bailer AJ. 2009. Comparing model averaging with other model selection strategies for benchmark dose estimation. Environ Ecol Stat 16:37-51; doi: 10.1007/s10651-007-0071-7.
View Abstract2008 (7 POSTS)
Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants
DeWoskin RS, Thompson CM. 2008. Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants. Regul Toxicol Pharmacol 51(June):66–86; doi: 10.1016/j.yrtph.2008.02.005.
View AbstractA PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry
Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM. 2008. A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. Inhal Toxicol 20(4):375–390; doi: 10.1080/08958370801903750.
View AbstractAnti-inflammatory modulation of chronic airway inflammation in the murise house dust mite model
Ulrich K, Hincks JS, Walsh R, Caroline Wetterstrand EM, Fidock MD, Sreckovic S, Lamb DJ, Douglas GJ, Yeadon M, Perros-Huguet C, Evans SM. 2008. Anti-inflammatory modulation of chronic airway inflammation in the murise house dust mite model. Pulmon Pharmacol Therapeut 21(4):637–647; doi: 10.1016/j.pupt.2008.02.006.
View AbstractWorker exposure to secondhand smoke: Evaluating a prediction model
James HR, Barfield L, Britt JK, James RC. 2008. Worker exposure to secondhand smoke: Evaluating a prediction model. Prof Saf Sep:34-44.
View AbstractModel averaging software for dichotomous dose response risk estimation
Wheeler MW, Bailer AJ. 2008. Model averaging software for dichotomous dose response risk estimation. J Stat Software 26(5):1-15; doi: 10.18637jss.v026.i05.
View AbstractSimulation of VX exposure in multiple species by means of a physiologically based pharmacokinetic/pharmacodynamic model
Gearhart JM, Covington TR, Robinson PJ, Whalley CE, McGuire JM, Evans RA, et al. Simulation of VX exposure in multiple species by means of a physiologically based pharmacokinetic/pharmacodynamic model. Poster presented at the Bioscience Review Conference, Baltimore, MD, May 2008.
Approaches for applications of physiologically based pharmacokinetic models in risk assessment
Thompson CM, Sonawane B, Barton HA, DeWoskin RS, Schlosser P, Lipscomb JC, Chiu W, Krishnan K. 2008. Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health B 11(7):519–547; doi: 10.1080/10937400701724337.
View Abstract2007 (3 POSTS)
A physiologically-based pharmacokinetic model for developmental exposure to PBDE-47 in rodents
Emond C, Raymer J, Garner E, Diliberto J, Staskal D, Birnbaum LS. A physiologically-based pharmacokinetic model for developmental exposure to PBDE-47 in rodents. Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 2007.
Properties of model‐averaged BMDLs: A study of model averaging in dichotomous response risk estimation
Wheeler MW, Bailer AJ. 2007. Properties of model‐averaged BMDLs: A study of model averaging in dichotomous response risk estimation. Risk Anal 7(3):659-70; doi: 10.1111/j.1539-6924.2007.0090.x. PMID: 17640214.
View AbstractA pharmacokinetic model of the intracellular dosimetry of inhaled nickel
Hack CE, Covington TR, Lawrence G, Shipp AM, Gentry R, Yager J, Clewell, HJ, III. 2007. A pharmacokinetic model of the intracellular dosimetry of inhaled nickel. J Toxicol Environ Health A 70(5):445–464; doi: 10.1080/15287390600870726.
View Abstract2006 (2 POSTS)
Retrospective modeling of potential residential exposure to perfluorooctanoic acid (PFOA) releases from a manufacturing facility
Paustenbach DJ, Panko JM, Scott PK, Unice KM. Retrospective modeling of potential residential exposure to perfluorooctanoic acid (PFOA) releases from a manufacturing facility. Society of Toxicology 45th Annual Meeting, San Diego, CA, March 2006.
Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose-response modeling in mice
Marino DJ, Clewell HJ, Gentry PR, Covington TR, Hack CE, David RM, Morgott DA. 2006. Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose-response modeling in mice. Regul Toxicol Pharmacol 45(1):44–54; doi: 10.1016/j.yrtph.2005.12.007.
View Abstract2005 (6 POSTS)
In vivo models of ocular injury and recovery: Current and potential biomarkers to support development and validation of predictive in vitro models
Stokes WS, Chambers W, Bonner M, Allen DG, Tice RR, Choksi NY, et al. In vivo models of ocular injury and recovery: Current and potential biomarkers to support development and validation of predictive in vitro models. Presented at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, Germany, August 2005.
Development of exposure assessment models for indoor air exposure to elemental mercury
Unice KM, Panko JM, Scott PK. Development of exposure assessment models for indoor air exposure to elemental mercury. International Society for Exposure Assessment Conference, 2005.
Comparison of toluene exposures during spray painting using various consumer product exposure models
Panko JM, Unice KM, Brown JL. Comparison of toluene exposures during spray painting using various consumer product exposure models. International Society for Exposure Assessment Conference, 2005.