Latest News

ToxStrategies scientists have published a new research article assessing the in vivo genotoxicity of hexavalent chromium [Cr(VI)] following ingestion via drinking water, in Toxicology and Applied Pharmacology. This new article is an extension of our earlier paper demonstrating the lack of mutagenic response in the oral mucosa of Big Blue® TgF344 rats exposed to 180,000 ppb Cr(VI). The latest article examines the mutagenic response in duodenum tissues archived from our previous study. Similar to the read more…

Dr. Rayetta Henderson and Ms. Alea Goodmanson attended and exhibited at the annual Institute of Food Technologists (IFT) Meeting & Expo, held June 25-28 in Las Vegas, NV.  IFT aims to transform scientific knowledge into innovative solutions for the global food system, and their annual meeting creates a dynamic forum to present the newest advancements in food science and technology. We look forward to attending and exhibiting at IFT 2018 in Chicago, IL!

ToxStrategies scientists were recently invited to contribute an article to the special issue “Genomic Toxicology: Epigenetics” in Current Opinion in Toxicology. An overview of relationships between chemical-induced changes in epigenetic mechanisms, including histone modifications, DNA methylation, and microRNA expression, and genotoxicity were reviewed and presented. Several examples of chemical carcinogens for which epigenetic alterations and DNA damage have been previously demonstrated were discussed. Examples included: (i) preferential binding of reactive chemicals or metabolites to methylated read more…

We are pleased to announce that Dr. William (Bill) Rish has joined ToxStrategies, Inc., as a Principal Engineer in Dublin (Columbus), Ohio. Dr. Rish is an engineer  and public policy specialist with over 35 years’ experience in engineering, environmental science, risk assessment, and uncertainty analysis. He has been active on numerous advisory committees and work groups in the development of federal and state regulatory rules, guidance, and cleanup standards. He has also been the project read more…

On June 22, 2017, the U.S. EPA issued a seminal guidance document related to the implementation of the LCSA –  “Guidance to Assist Interested Persons in Developing and Submitting Draft Risk Evaluations under the Toxic Substances Control Act”.  The LCSA required the USEPA to develop this guidance to assist external parties in submitting draft risk evaluations for consideration by the USEPA. The guidance states that “EPA’s vision is to have a sustainable TSCA program that read more…

ToxStrategies scientists recently published a paper in Environment International regarding the estimation of toxic equivalency (TEQ) concentrations of dioxin-like compounds (DLCs) in the US population from 2001 to 2008, using NHANES data. The paper addresses the issue of the use of pooled samples in the two most recent NHANES biennials for which DLC data is available (2005-2006 and 2007-2008). In previous biennials, participants’ serum samples were analyzed individually. The use of pooled samples prevents reliable read more…

Mrs. Camarie Perry and Ms. Alea Goodmanson will be at the annual TCEQ Environmental Trade Fair & Conference next week in Austin, TX.  They’re looking forward to seeing some familiar faces, so stop by and visit them at booth #521!

ToxStrategies scientists published a study in Toxicological Sciences aimed at contributing to the understanding of Cr(VI) MOA by evaluating high-throughput screening (HTS) data and other in vitro data relevant to Cr(VI), and comparing these findings to robust in vivo data, including transcriptomic profiles in target tissues. Emerging methods were used to evaluate the HTS data, including mapping of assays to the proposed Ten Key Characteristics of Carcinogens (TKCCs), incorporation of potential cytotoxicity interference, and comparison read more…