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On March 20, 2019, the EPA released lists of the next 20 high-priority and 20 low-priority existing chemicals that are candidates for TSCA risk evaluations. The Agency released this list to provide the public an opportunity to submit relevant information over the next 90 days, such as the uses, hazards, and exposure for these chemicals. Publication also activates a statutory requirement for EPA to complete the prioritization process in the next 9 to 12 months, read more…

ToxStrategies’ scientists continue to develop innovative solutions to address some of the most challenging scientific issues that face our clients.  Several recent examples of such projects were presented at the Society of Toxicology 58th Annual Meeting. The SOT 2019 conference was held in Baltimore, MD (March 10–14, 2019). To see a list of our presentations, click here,  and if you would like to receive a copy of one, please contact us.

On February 14, EPA released its first-ever comprehensive nationwide Per- and Polyfluoralkyl Substances (PFAS) Action Plan. The plan is the result of a cross-agency effort and is focused predominantly on protecting the nation’s drinking water. The PFAS Action Plan includes numerous aspects that may have both immediate and long-term effects on regulated parties: EPA will work toward establishment of Maximum Contaminant Levels (MCLs) under the Safe Drinking Water Act, potentially complicating the regulatory landscape with additional read more…

One of the most perplexing issues when distributing animal feeds and feed ingredients in the US is determining how to accurately register and license both the guarantor and products, to be in compliance for national distribution.  A guarantor, the name of the company listed on the feed label or package, is responsible for complying with all applicable food regulations, which include a variety of registrations.  If products are distributed nationally, they must be registered with read more…

A new article from ToxStrategies authors describes a framework to systematically and quantitatively integrate mechanistic data in assessments of potential carcinogenicity. The framework builds on the key characteristics organizational approach that is being implemented by authoritative bodies globally, by accounting for the quality and relevance of individual studies when developing weight-of-evidence conclusions regarding the activity of key characteristics. The proposed framework provides a flexible solution to quantitively integrate all available data in a systematic and read more…

The Center of Excellence in 21st Century Toxicology (21CT; a division of ToxStrategies) was well represented at the 44th annual summer meeting of The Toxicology Forum (TFF), held July 9–11 in Baltimore. Dr. Susan Borghoff, 21CT Director, served on the Organizing Committee, and also participated in the session titled, “Integration of Toxicokinetics and the Kinetically-Derived Maximum Dose into Toxicity Testing and Risk Assessment.” Dr. Borghoff’s presentation was, “Kinetically Derived Maximum Dose: A Key Initiating Event Impacting Need for read more…