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ToxStrategies authors, Dr. Daniele Wikoff and Dr. Allison Franzen, and colleagues have published a framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing uncertainty. It provides a stepwise and adaptive approach to apply evidence-based methods for the facilitation of risk assessment. This framework, published in Regulatory Toxicology and Pharmacology, is titled “Facilitation of risk assessment with evidence-based methods – A framework for use of systematic mapping and systematic read more…

ToxStrategies scientist, Ms. Ann Verwiel, will be presenting during the upcoming virtual 30th annual meeting of the International Society of Exposure Science. Ms. Verwiel’s poster is titled Risk Management for VOCs in Indoor Air and Building Evacuation Decisions and will be available to registrants until September 22, 2021. Ms. Verwiel’s work examines the use of conservative screening levels in addressing potential vapor intrusion to inform significant decisions such as building evacuations. The meeting will be read more…

ToxStrategies scientist, Dr. Laurie Haws, will be presenting in a virtual session at the upcoming Science of PFAS: Chemistry, Health, and Multimedia Measurements virtual conference sponsored by the Air & Waste Management Association.  Dr. Haws’ presentation, titled Risk Characterization of PFAS-Challenges and Opportunities, will be live streamed on September 15, 2020, during the PFAS Health Effects session at 12:45-2:45 EST.  In addition to live-stream access, all presentations will be available to meeting registrants through the read more…

EpidStrategies scientists have collaborated with toxicologists from ToxStrategies’ Biopharmaceuticals/Pharmaceuticals Practice to produce a white paper that provides “Critical insights into nonclinical toxicology and real-world evidence essential for a successful rare disease product launch.” The paper summarizes how well-designed nonclinical studies, coupled with an understanding of the epidemiology and natural history of the condition, can support a clinical program in the rare disease arena.  

ToxStrategies scientists published a GLP OECD designed reproductive toxicity study (Thompson et al., 2020) assessing the potential for adverse follicular effects in mice following exposure to hexavalent chromium [Cr(VI)] in drinking water. This study demonstrated that reproductive toxicity was limited to extremely high doses that are not environmentally-relevant.  At Cr(VI) doses consistent with, and substantially higher than, the basis for the California Proposition 65 Maximum Allowable Dose Level (MADL), no effects are observed, supporting that read more…

FDA is warning consumers and health care providers that they have seen a sharp increase in hand sanitizer products labeled to contain ethanol but that have tested positive for methanol contamination. The FDA has developed a searchable list to help consumers identified whether those hand sanitizer products that are being recalled or confirmed to contain methanol contamination. Consumers can access the searchable list here:

The Toxicology Forum will convene a series of virtual sessions in July and August 2020. The goal of these sessions is to facilitate dialogue and information exchange among presenters, panelists, and attendees. ToxStrategies scientists Drs. Candace Doepker and Susan Borghoff will present recent work related to the application of new approach methods (NAMS). In the July 20th session, titled “Strategies to Use Non-Animal Approaches in Food Safety Assessment,” Dr. Doepker will discuss food regulations and read more…

An international group of experts, including ToxStrategies scientist Dr. Daniele Wikoff, has developed and published a comprehensive framework for the planning and conduct of high-quality Systematic Reviews (SRs).  Derived from existing standards of Systematic Review used in biomedicine, the Conduct of Systematic Reviews in Toxicology and Environmental Health Research (COSTER) standard outlines 70 requirements spanning various research methodology considerations and establishes the first overarching code for Systematic Review in environmental health studies. Published in Environment read more…