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Growing Need for Cumulative Exposure and Cumulative Risk Assessment

Understanding the Full Picture of Chemical and Environmental Exposures Regulators, industry, and the public are increasingly focused on the combined effects of multiple chemicals and environmental stressors on human health. Recently, the Make Our Children Healthy Again Assessment The MAHA Report – The White House identified exposure to an “aggregation of environmental chemicals” and exposure to food additives among the key drivers behind child health issues. Traditional “aggregate” risk assessments have estimated exposures to individual chemicals read more…

13 State AG’s Issue Guidance – Environmental Justice Initiatives Remain Necessary and Legal

Multi-State Guidance Affirming the Importance and Legality of Environmental Justice Initiatives   The Attorneys General of California, Massachusetts, and New York, joined by the Attorneys General of Arizona, Connecticut, Delaware, Hawaii, Illinois, Maryland, Minnesota, Oregon, Rhode Island, and Vermont, issue this Guidance to affirm the importance and legality of efforts to advance environmental justice, which seek a healthy environment for all people across the United States in which to live, play, work, learn, and worship. read more…

MTAP is a promising target for cancer therapy.

EpidStrategies’ scientists Mina Suh, Naimisha Movva, and Sue Pastula have authored a new systematic literature review in Cancer Treatment and Research Communications. This review summarizes the prevalence of MTAP deletions or loss of expression and accompanying prognostic impacts in adult and pediatric patients with specific solid or hematologic cancers. This systematic literature review is the first to comprehensively describe and summarize current MTAP evidence across several solid and hematologic cancers. High prevalence of MTAP homozygous deletions or loss of protein expression read more…

Opportunity for Updates on State Environmental Justice Programs and Cumulative Impact Assessment Requirements: Timely and Effective Solutions

Executive Orders issued since President Trump’s inauguration have eliminated all federal programs relating to environmental justice (EJ), including at EPA. Nevertheless, the need to assess potential cumulative impacts will continue where permits, commercial/industrial development, or regulatory decisions may impact vulnerable communities because: At least a dozen states have laws requiring Cumulative Impact Assessment (CIA), usually related to permitting, where potential impact on vulnerable communities exists. Each state has its own way to identify such communities, read more…

ToxStrategies Expands Expertise in Regulatory Toxicology

We are pleased to announce the addition of Timothy W. Robison, PhD, DABT, who has 29 years of experience at the US Food and Drug Administration as a Reviewer, Team Leader, and Supervisor, working with multidisciplinary teams to support development of drugs for pulmonary, allergy, critical care, autoimmune, transplant, and viral (e.g., COVID) indications. His expertise includes evaluation of inhalation, oral, and parenteral toxicology studies, genetic toxicity studies with drug candidates and impurities, and extractables read more…

ToxStrategies’ scientists publish paper on consumer product exposure to vinyl acetate monomer

ToxStrategies’ scientists Jennifer Bare, Mandie Kramer, and Susan Borghoff are excited share their new paper on consumer product exposure to vinyl acetate monomer (VAM). The team partnered with the Vinyl Acetate Council, who provided funding for the research, and analytical chemists and toxicologists from LyondellBasell Industries, who developed methods for determining VAM in a variety of consumer products. ToxStrategies subsequently modeled consumer exposure to a variety of household products containing residual VAM using EPA’s Consumer read more…

Is it Clean Enough? Reoccupancy After Fires

It is crucial to complete post-fire assessments before a home is reoccupied. ToxStrategies’ team of industrial hygienists are experienced in evaluating homes affected by wildfire smoke. Our team applies scientific methods and industry best practices, including the recently published second edition of the American Industrial Hygiene Association AIHA Technical Guide for Wildfire Smoke Impact Assessments, to assess fire-impacted properties. With experience in post-fire assessments, sampling strategies, and impact categorization, we provide the data-driven insights needed read more…

BlueRidge Life Sciences’ Dr. Naomi Sacks is at ISPOR!

Dr. Naomi Sacks, Vice President, BlueRidge Life Sciences’ Pharmaceutical Commercialization division, is attending the annual meeting of ISPOR (The Professional Society for Health Economics and Outcomes Research), which is being held in Montreal, Canada, May 13–16, 2025. She is a co-author on a poster presentation, “Healthcare Resource Utilization for Medicare Patients with Non-Cystic Fibrosis Bronchiectasis (NCFB) and Exacerbations Coinfected with Pseudomonas aeruginosa.” If you are at ISPOR—or if you would like to learn more about BlueRidge read more…

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