Publications
Susan Borghoff, M.S.P.H., Ph.D., DABT (73 POSTS)
2024 (12 POSTS)
Optimizing androgen receptor prioritization using high-throughput assay-based activity models
Bever RJ, Edwards SW, Antonijevic T, Nelms MD, Ring C, Harris D, Lynn SG, Williams D, Chappell G, Boyles R, Borghoff S, Markey KJ. 2024. Optimizing androgen receptor prioritization using high-throughput assay-based activity models. Front Toxicol 6(March 11):1347364; doi: 10.3389/ftox.2024.1347364. PMID: 38529103.
View Abstract2023 (3 POSTS)
Oral toxicity evaluation of cannabidiol
Henderson RG, Lefever TW, Heintz MM, Trexler KR, Borghoff SJ, Bonn-Miller MO. 2023. Oral toxicity evaluation of cannabidiol. Food Chem Toxicol 176(June):113786; doi: 10.1016/j.fct.2023.113778. PMID: 37105391.
View AbstractReproductive and developmental toxicity evaluation of cannabidiol
Henderson RG, Welsh BT, Rogers JM, Borghoff SJ, Trexler KR, Bonn-Miller MO, Lefever TW. 2023. Reproductive and developmental toxicity evaluation of cannabidiol. Food Chem Toxicol 176(June):113786; doi: 10.1016/j.fct.2023.113786. PMID: 37105390.
View AbstractUpdated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame
Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.
View Abstract2022 (3 POSTS)
Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats
Goyak KO, Sarang SS, Franzen A, Borghoff SJ, Ryman-Rasumssen JP. 2022. Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats. Crit Rev Toxicol 52(5):345-357; doi: 10.1080/10408444.2022.2082269. PMID: 35862579.
View AbstractAssessment of the applicability of the threshold of toxicological concern for per- and polyfluoroalkyl substances
Lea IA, Pham LL, Antonijevic T, Thompson C, Borghoff SJ. 2022. Assessment of the applicability of the threshold of toxicological concern for per- and polyfluoroalkyl substances. Regul Toxicol Pharmacol 133(August):105190; doi: 10.1016/j.yrtph.2022.105190. PMID: 35662637.
View AbstractSystematic literature review and critical appraisal of mammalian reproductive studies evaluation potential effects associated with microplastics
Fitch S, Wikoff D, Britt J, Lea I, Brown L, Borghoff S, et al. 2022. Systematic literature review and critical appraisal of mammalian reproductive studies evaluation potential effects associated with microplastics. OSF | Systematic Literature Review and Critical Appraisal of Mammalian Reproductive Studies Evaluation Potential Effects Associated with Microplastics
View Abstract2021 (7 POSTS)
Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs)
Wikoff D, Edwards S, Angrish M, Baumgartner, Bever R, Borghoff S, Chappell G, Chew R, Fitch S, Hench G, Hamernik K, Henderson D, Kirk A, Lea I, Mandel M, Payne L, Shapiro S, Urban J, Williams D, Markey K. Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs). Presented at 10th annual meeting of American Society for Cellular and Computational Toxicology (virtual), October 2021.
View AbstractRNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days
Black MB, Andersen ME, Pendse SN, Borghoff SJ, Streicker M, McMullen PD. 2021. RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days. Data in Brief 38(Oct):107420; doi: 10.1016/j.dib.2021.107420. PMID: 34660856.
View AbstractRE: Response to the Office of Environmental Health Hazard Assessment on comments related to Gentry et al. (2021)
Gentry R, Rodricks J, Clewell H, Greene T, Chappell G, Lea I, Borghoff S, Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A. 2021. RE: Response to the Office of Environmental Health Hazard Assessment on comments related to Gentry et al. (2021). Food Chem Toxicol 152(June):112202; doi: 10.1016/j.fct.2021.112202. PMID: 33872725.
View AbstractIntegration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors
Gentry R, Greene T, Chappell G, Lea I, Borghoff S, Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A, Rodricks J, Clewell H. 2021. Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors. Food Chem Toxicol 151(May):112097; doi: 10.1016/j.fct.2021.112097. PMID: 33677041.
View AbstractCase-study applications using evidence-based approaches to assess endocrine activity for risk assessment
Wikoff D, Fitch S, Borghoff S. Case-study applications using evidence-based approaches to assess endocrine activity for risk assessment. Invited speaker (Wikoff): 61st Annual Meeting (virtual) of the Society for Birth Defects Research & Prevention, June 2021.
View AbstractA systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole
Borghoff SJ, Fitch SE, Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124(Aug):104977; doi: 10.1016/j.yrtph.2021.104977. PMID: 34174380.
View AbstractLack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS. 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150(April):112045; doi: 10.1016/j.fct.2021.112045. PMID: 33587976.
View Abstract2020 (6 POSTS)
Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values
Pham LL, Borghoff SJ, Thompson CM. 2020. Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values. Regul Toxicol Pharmacol 113(June):104651; doi: 10.1016/j.yrtph.2020.104651.
View AbstractLack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence
Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141(July):111375; doi: 10.1016/j.fct.2020.111375.
View AbstractRecent publication on assessment of mechanistic data for synthetic food dyes and neurobehavioral signals
Chappell GA, Britt JK, Borghoff, SJ. 2020. Systematic assessment of mechanistic data for FDA-certified food colors and neurodevelopmental processes. Food Chem Toxicol 140:111310 [open access].
View AbstractAn adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N)
Franzen A, Borghoff SJ. An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N). Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.
View AbstractLack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence
Chappell GA, Borghoff SJ, Pham L, Doepker CL, Wikoff DS. 2020. Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110898; doi: 10.1016/j.fct.2019.110898.
View AbstractLack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence
Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110866; doi: 10.1016/j.fct.2019.110866.
View Abstract