Publications

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Isabel Lea (47 POSTS)

2019 (4 POSTS)

NTP high-level summary data collections in the Chemical Effects in Biological Systems (CEBS) database

Sheridan E, Moose J, Liu Y, Martini C, Lea I, Fostel J. NTP high-level summary data collections in the Chemical Effects in Biological Systems (CEBS) database. Poster PS01-0606. Presented at 15th International Congress of Toxicology, Honolulu, HI, July 2019.

Access to National Toxicology Program histopathology lesion collection in Chemical Effects in Biological Systems (CEBS) database

Bhawana B, Lea I, Liu Y, Martini C, Fostel J. Access to National Toxicology Program histopathology lesion collection in Chemical Effects in Biological Systems (CEBS) database. Poster P040. Presented at the 38th Annual Symposium of Society for Toxicologic Pathology, Raleigh, NC, June 2019.

Hallmark gene set annotation for NTP toxicogenomic studies

Lea I, Liu Y, Sheridan E, Motti D, Martini C, Fostel J, Auerbach S. Hallmark gene set annotation for NTP toxicogenomic studies. Abstract #1743-P119. Presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

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Integrating assay datasets into Chemical Effects in Biological Systems (CEBS)

Martini C, Liu Y, Motti D, Johnson J, McCormick K, Lea I, Fostel F. Integrating assay datasets into Chemical Effects in Biological Systems (CEBS). Abstract #1749-P125, Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

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2018 (1 POST)

Improved searching in the Chemical Effects in Biological Systems (CEBS) database leads to greater utility of NTP data

Sheridan ER, Jackson M, Paleja A, Martini C, Rashid A, Lea I, Fostel J. Improved searching in the Chemical Effects in Biological Systems (CEBS) database leads to greater utility of NTP data. Abstract 2525-P887, Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

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2017 (6 POSTS)

Benchmark dose analysis of Chemical Effects in Biological Systems (CEBS) datasets

Lea I, Yang L, Rashid A, Fostel JM. Benchmark dose analysis of Chemical Effects in Biological Systems (CEBS) datasets. Abstract 2918-P412. Presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

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Chemical Effects in Biological Systems (CEBS) database: Treatment-related findings

Martini C, Rashid A, Paleja A, Lea I, Fostel JM. Chemical Effects in Biological Systems (CEBS) database: Treatment-related findings. Abstract 1381-P119. Presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

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Using the Chemical Effects in Biological Systems (CEBS) database to answer pathology questions

Sheridan E, Martini C, Shaw M, Shockley K, Brix A, Rashid A, Lea I, Fostel J. Using the Chemical Effects in Biological Systems (CEBS) database to answer pathology questions. Poster P035. Presented at the 36th Annual Symposium of Society for Toxicologic Pathology, Montreal, Quebec, Canada, June 2017.

The TGx-28.65 biomarker — A web-based application using transcriptomics to identify DNA damage-inducing chemicals

Jackson M, Yang L, Yauk CL, Lea I, Kuo B, Williams A, Rashid A, Fostel J. The TGx-28.65 biomarker — A web-based application using transcriptomics to identify DNA damage-inducing chemicals. Abstract 1224. Presented at the 48th Annual Meeting of Environmental Mutagenesis and Genomics Society, Raleigh, NC, September 2017.

The TGx-28 65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures

Jackson MA, Yang L, Lea I, Rashid A, Kuo B, Williams A, Lyn Yauk C, Fostel J. 2017. The TGx-28 65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures. Environ Mol Mutagen 58(7):529–535; doi: 10.1002/em.22114.

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A comprehensive annotated database of toxicological data

Lea IA, Gong H, Paleja A, Rashid, A, Foster J. 2017. CEBS: A comprehensive annotated database of toxicological data. Nucleic Acids Res 45(D1):D964–D971; doi: 10.1093/nar/gkw1077.

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2015 (1 POST)

Chemical Effects in Biological Systems (CEBS) database: Advanced histopathology search applications

Lea I, Rashid A, Favaro C, Fostel J. Chemical Effects in Biological Systems (CEBS) database: Advanced histopathology search applications. Abstract 2195-P410. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.

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2014 (1 POST)

Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3′,4,4′-tetrachloroazobenzene

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth NJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ. 2014. Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3′,4,4′-tetrachloroazobenzene. Toxicol Pathol 42(3):555–564; doi: 10.1177/0192623313491169.

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2010 (1 POST)

Characterizing and predicting carcinogenicity and mode-of-action using conventional and toxicogenomics methods

Waters MD, Jackson MA, Lea IA. 2010. Characterizing and predicting carcinogenicity and mode-of-action using conventional and toxicogenomics methods. Mutat Res 705(3):184–200; doi: 10.1016/j.mrrev.2010.04.005.

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2009 (1 POST)

Genetic pathways to colorectal cancer

Lea IA, Jackson MA, Dunnick JK. 2009. Genetic pathways to colorectal cancer. Mutat Res 670(1–2):96–98; doi: 10.1016/j.mrfmmm.2009.06.011.

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2007 (1 POST)

Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns

Lea IA, Jackson MA, Li X, Bailey S, Peddada SD, Dunnick JK. 2007. Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns. Carcinogenesis 28(9):1851–1858; doi: 10.1093/carcin/bgm176.

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2006 (1 POST)

Genetic alterations in cancer knowledge system: Analysis of gene mutations in mouse and human liver and lung tumors

Jackson MA, Lea I, Rashid A, Peddada SD, Dunnick JK. 2006. Genetic alterations in cancer knowledge system: Analysis of gene mutations in mouse and human liver and lung tumors. Toxicol Sci 90(2):400–418; doi: 10.1093/toxsci/kfj101.

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2004 (1 POST)

Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella

Lea IA, Widgren EE, O’Rand MG. 2004. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Reprod Biol Endocrinol 2(Jul 16):57; doi: 10.1186/1477-7827-2-57.

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2002 (1 POST)

Analysis of recombinant mouse zona pellucida protein 2 (ZP2) constructs for immunocontraception

Lea IA, Widgren EE, O’Rand MG. 2002. Analysis of recombinant mouse zona pellucida protein 2 (ZP2) constructs for immunocontraception. Vaccine 20(11–12):1515–1523; doi: 10.1016/S0264-410X(01)00514-X.

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2001 (1 POST)

Zonadhesin: Characterization, localization, and zona pellucida binding

Lea IA, Sivashanmugam P, O’Rand MG. 2001. Zonadhesin: Characterization, localization, and zona pellucida binding. Biol Reprod 65(6):1691–700; doi: 10.1095/biolreprod65.6.1691.

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